Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice

The expansion of follicular helper T (Tfh) cells, which is tightly associated with the development of lupus, is reversed by the inhibition of either glycolysis or glutaminolysis in mice. Here we analyzed the gene expression and metabolome of Tfh cells and naive CD4(+) T (Tn) cells in the B6.Sle1.Sle...

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Detalles Bibliográficos
Autores principales: Gong, Minghao, Choi, Seung-Chul, Park, Yuk Pheel, Zou, Xueyang, Elshikha, Ahmed S., Gerriets, Valerie A., Rathmell, Jeffrey C., Mohamazadeh, Mansour, Morel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197114/
https://www.ncbi.nlm.nih.gov/pubmed/37216123
http://dx.doi.org/10.1016/j.isci.2023.106774

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