Profiling Enzyme Activity of l-Asparaginase II by NMR-Based Methyl Fingerprinting at Natural Abundance

[Image: see text] l-asparaginase II (MW 135 kDa) from E. coli is an FDA-approved protein drug used for the treatment of childhood leukemia. Despite its long history as a chemotherapeutic, the structural basis of enzyme action, in solution, remains widely contested. In this work, methyl-based 2D [(1)...

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Detalles Bibliográficos
Autores principales: Nag, Rachayita, Joshi, Srishti, Rathore, Anurag Singh, Majumder, Subhabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197121/
https://www.ncbi.nlm.nih.gov/pubmed/37154467
http://dx.doi.org/10.1021/jacs.3c02154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197121/
https://www.ncbi.nlm.nih.gov/pubmed/37154467
http://dx.doi.org/10.1021/jacs.3c02154

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