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Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders
[Image: see text] Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that the gut and brain are in constant bidirectional communication, of which gut microbiota and its metabolic production are a major component, and form...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197139/ https://www.ncbi.nlm.nih.gov/pubmed/37156006 http://dx.doi.org/10.1021/acschemneuro.3c00127 |
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author | Sasso, Janet M. Ammar, Ramy M. Tenchov, Rumiana Lemmel, Steven Kelber, Olaf Grieswelle, Malte Zhou, Qiongqiong Angela |
author_facet | Sasso, Janet M. Ammar, Ramy M. Tenchov, Rumiana Lemmel, Steven Kelber, Olaf Grieswelle, Malte Zhou, Qiongqiong Angela |
author_sort | Sasso, Janet M. |
collection | PubMed |
description | [Image: see text] Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that the gut and brain are in constant bidirectional communication, of which gut microbiota and its metabolic production are a major component, and form the so-called gut microbiome–brain axis. Disturbances of microbiota homeostasis caused by imbalance in their functional composition and metabolic activities, known as dysbiosis, cause dysregulation of these pathways and trigger changes in the blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological and functional gastrointestinal disorders. In turn, the brain can affect the structure and function of gut microbiota through the autonomic nervous system by regulating gut motility, intestinal transit and secretion, and gut permeability. Here, we examine data from the CAS Content Collection, the largest collection of published scientific information, and analyze the publication landscape of recent research. We review the advances in knowledge related to the human gut microbiome, its complexity and functionality, its communication with the central nervous system, and the effect of the gut microbiome–brain axis on mental and gut health. We discuss correlations between gut microbiota composition and various diseases, specifically gastrointestinal and mental disorders. We also explore gut microbiota metabolites with regard to their impact on the brain and gut function and associated diseases. Finally, we assess clinical applications of gut-microbiota-related substances and metabolites with their development pipelines. We hope this review can serve as a useful resource in understanding the current knowledge on this emerging field in an effort to further solving of the remaining challenges and fulfilling its potential. |
format | Online Article Text |
id | pubmed-10197139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101971392023-05-20 Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders Sasso, Janet M. Ammar, Ramy M. Tenchov, Rumiana Lemmel, Steven Kelber, Olaf Grieswelle, Malte Zhou, Qiongqiong Angela ACS Chem Neurosci [Image: see text] Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that the gut and brain are in constant bidirectional communication, of which gut microbiota and its metabolic production are a major component, and form the so-called gut microbiome–brain axis. Disturbances of microbiota homeostasis caused by imbalance in their functional composition and metabolic activities, known as dysbiosis, cause dysregulation of these pathways and trigger changes in the blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological and functional gastrointestinal disorders. In turn, the brain can affect the structure and function of gut microbiota through the autonomic nervous system by regulating gut motility, intestinal transit and secretion, and gut permeability. Here, we examine data from the CAS Content Collection, the largest collection of published scientific information, and analyze the publication landscape of recent research. We review the advances in knowledge related to the human gut microbiome, its complexity and functionality, its communication with the central nervous system, and the effect of the gut microbiome–brain axis on mental and gut health. We discuss correlations between gut microbiota composition and various diseases, specifically gastrointestinal and mental disorders. We also explore gut microbiota metabolites with regard to their impact on the brain and gut function and associated diseases. Finally, we assess clinical applications of gut-microbiota-related substances and metabolites with their development pipelines. We hope this review can serve as a useful resource in understanding the current knowledge on this emerging field in an effort to further solving of the remaining challenges and fulfilling its potential. American Chemical Society 2023-05-08 /pmc/articles/PMC10197139/ /pubmed/37156006 http://dx.doi.org/10.1021/acschemneuro.3c00127 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Sasso, Janet M. Ammar, Ramy M. Tenchov, Rumiana Lemmel, Steven Kelber, Olaf Grieswelle, Malte Zhou, Qiongqiong Angela Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders |
title | Gut Microbiome–Brain
Alliance: A Landscape
View into Mental and Gastrointestinal Health and Disorders |
title_full | Gut Microbiome–Brain
Alliance: A Landscape
View into Mental and Gastrointestinal Health and Disorders |
title_fullStr | Gut Microbiome–Brain
Alliance: A Landscape
View into Mental and Gastrointestinal Health and Disorders |
title_full_unstemmed | Gut Microbiome–Brain
Alliance: A Landscape
View into Mental and Gastrointestinal Health and Disorders |
title_short | Gut Microbiome–Brain
Alliance: A Landscape
View into Mental and Gastrointestinal Health and Disorders |
title_sort | gut microbiome–brain
alliance: a landscape
view into mental and gastrointestinal health and disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197139/ https://www.ncbi.nlm.nih.gov/pubmed/37156006 http://dx.doi.org/10.1021/acschemneuro.3c00127 |
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