Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants

We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed aptamers which can recognise all variants, from the original wild-type ‘Wuhan’ str...

Descripción completa

Detalles Bibliográficos
Autores principales: Le, Thao T., Benton, Donald J., Wrobel, Antoni G., Gamblin, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197177/
https://www.ncbi.nlm.nih.gov/pubmed/37213341
http://dx.doi.org/10.1039/d3ra01382k
Descripción
Sumario:We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed aptamers which can recognise all variants, from the original wild-type ‘Wuhan’ strain to Omicron, with high affinity (K(d) values in the pM range).

Ejemplares similares