In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts

OBJECTIVE: Ganoderma extracts have the potential to be used as anti-cancer, anti-inflammatory, immunomodulator, and antimicrobial agents, as evaluated in numerous studies. This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganode...

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Autores principales: ahmadi, Mohammad, Salimi, Mahboobeh, Saraei, Mehrzad, Nezhad, Niloofar Salavati, Javadi, Amir, Mohammadi, Faezeh, Heydarian, Peyman, Ali, Ehsan, Hajialilo, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
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Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197208/
https://www.ncbi.nlm.nih.gov/pubmed/37202827
http://dx.doi.org/10.1186/s13104-023-06355-6
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author ahmadi, Mohammad
Salimi, Mahboobeh
Saraei, Mehrzad
Nezhad, Niloofar Salavati
Javadi, Amir
Mohammadi, Faezeh
Heydarian, Peyman
Ali, Ehsan
Hajialilo, Elham
author_facet ahmadi, Mohammad
Salimi, Mahboobeh
Saraei, Mehrzad
Nezhad, Niloofar Salavati
Javadi, Amir
Mohammadi, Faezeh
Heydarian, Peyman
Ali, Ehsan
Hajialilo, Elham
author_sort ahmadi, Mohammad
collection PubMed
description OBJECTIVE: Ganoderma extracts have the potential to be used as anti-cancer, anti-inflammatory, immunomodulator, and antimicrobial agents, as evaluated in numerous studies. This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma lucidum on Toxoplasma gondii RH strain tachyzoites, in vitro. RESULTS: All three types of extracts showed toxoplasmacidal effects. The highest percentage of mortality was related to hydroalcoholic extract. The EC50 of Ganoderma extracts for tachyzoites were 76.32, 3.274, and 40.18 for aqueous, hydroalcoholic and alcoholic extracts, respectively. The selectivity index obtained for hydroalcoholic extract was 71.22, showing the highest activity compared to other extracts. According to our findings, the hydroalcoholic part was the most effective substance among the extracts. This basic study showed obvious anti-toxoplasma effect of Ganoderma lucidum extracts. These extracts can be used as candidates for further in-depth and comprehensive studies especially In vivo experiments to prevent toxoplasmosis.
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spelling pubmed-101972082023-05-20 In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts ahmadi, Mohammad Salimi, Mahboobeh Saraei, Mehrzad Nezhad, Niloofar Salavati Javadi, Amir Mohammadi, Faezeh Heydarian, Peyman Ali, Ehsan Hajialilo, Elham BMC Res Notes Research Note OBJECTIVE: Ganoderma extracts have the potential to be used as anti-cancer, anti-inflammatory, immunomodulator, and antimicrobial agents, as evaluated in numerous studies. This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma lucidum on Toxoplasma gondii RH strain tachyzoites, in vitro. RESULTS: All three types of extracts showed toxoplasmacidal effects. The highest percentage of mortality was related to hydroalcoholic extract. The EC50 of Ganoderma extracts for tachyzoites were 76.32, 3.274, and 40.18 for aqueous, hydroalcoholic and alcoholic extracts, respectively. The selectivity index obtained for hydroalcoholic extract was 71.22, showing the highest activity compared to other extracts. According to our findings, the hydroalcoholic part was the most effective substance among the extracts. This basic study showed obvious anti-toxoplasma effect of Ganoderma lucidum extracts. These extracts can be used as candidates for further in-depth and comprehensive studies especially In vivo experiments to prevent toxoplasmosis. BioMed Central 2023-05-18 /pmc/articles/PMC10197208/ /pubmed/37202827 http://dx.doi.org/10.1186/s13104-023-06355-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
ahmadi, Mohammad
Salimi, Mahboobeh
Saraei, Mehrzad
Nezhad, Niloofar Salavati
Javadi, Amir
Mohammadi, Faezeh
Heydarian, Peyman
Ali, Ehsan
Hajialilo, Elham
In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts
title In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts
title_full In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts
title_fullStr In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts
title_full_unstemmed In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts
title_short In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts
title_sort in vitro anti-toxoplasma gondii activity of ganoderma lucidum extracts
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197208/
https://www.ncbi.nlm.nih.gov/pubmed/37202827
http://dx.doi.org/10.1186/s13104-023-06355-6
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