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Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues

BACKGROUND: Investigation of cartilage and chondrocytes has revealed that the osteoarthritis risk marked by the independent DNA variants rs11583641 and rs1046934 mediate their effects by decreasing the methylation status of CpG dinucleotides in enhancers and increasing the expression of shared targ...

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Detalles Bibliográficos
Autores principales:	Kehayova, Yulia S., Wilkinson, J. Mark, Rice, Sarah J., Loughlin, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197248/ https://www.ncbi.nlm.nih.gov/pubmed/37208701 http://dx.doi.org/10.1186/s13075-023-03066-y

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