Cargando…
Gut microbiota in patients with kidney stones: a systematic review and meta-analysis
BACKGROUND: Mounting evidence indicates that the gut microbiome (GMB) plays an essential role in kidney stone (KS) formation. In this study, we conducted a systematic review and meta-analysis to compare the composition of gut microbiota in kidney stone patients and healthy individuals, and further u...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197343/ https://www.ncbi.nlm.nih.gov/pubmed/37208622 http://dx.doi.org/10.1186/s12866-023-02891-0 |
_version_ | 1785044532175306752 |
---|---|
author | Yuan, Tianhui Xia, Yuqi Li, Bojun Yu, Weimin Rao, Ting Ye, Zehua Yan, Xinzhou Song, Baofeng Li, Lei Lin, Fangyou Cheng, Fan |
author_facet | Yuan, Tianhui Xia, Yuqi Li, Bojun Yu, Weimin Rao, Ting Ye, Zehua Yan, Xinzhou Song, Baofeng Li, Lei Lin, Fangyou Cheng, Fan |
author_sort | Yuan, Tianhui |
collection | PubMed |
description | BACKGROUND: Mounting evidence indicates that the gut microbiome (GMB) plays an essential role in kidney stone (KS) formation. In this study, we conducted a systematic review and meta-analysis to compare the composition of gut microbiota in kidney stone patients and healthy individuals, and further understand the role of gut microbiota in nephrolithiasis. RESULTS: Six databases were searched to find taxonomy-based comparison studies on the GMB until September 2022. Meta-analyses were performed using RevMan 5.3 to estimate the overall relative abundance of gut microbiota in KS patients and healthy subjects. Eight studies were included with 356 nephrolithiasis patients and 347 healthy subjects. The meta-analysis suggested that KS patients had a higher abundance of Bacteroides (35.11% vs 21.25%, Z = 3.56, P = 0.0004) and Escherichia_Shigella (4.39% vs 1.78%, Z = 3.23, P = 0.001), and a lower abundance of Prevotella_9 (8.41% vs 10.65%, Z = 4.49, P < 0.00001). Qualitative analysis revealed that beta-diversity was different between the two groups (P < 0.05); Ten taxa (Bacteroides, Phascolarctobacterium, Faecalibacterium, Flavobacterium, Akkermansia, Lactobacillus, Escherichia coli, Rhodobacter and Gordonia) helped the detection of kidney stones (P < 0.05); Genes or protein families of the GMB involved in oxalate degradation, glycan synthesis, and energy metabolism were altered in patients (P < 0.05). CONCLUSIONS: There is a characteristic gut microbiota dysbiosis in kidney stone patients. Individualized therapies like microbial supplementation, probiotic or synbiotic preparations and adjusted diet patterns based on individual gut microbial characteristics of patients may be more effective in preventing stone formation and recurrence. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-023-02891-0. |
format | Online Article Text |
id | pubmed-10197343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101973432023-05-20 Gut microbiota in patients with kidney stones: a systematic review and meta-analysis Yuan, Tianhui Xia, Yuqi Li, Bojun Yu, Weimin Rao, Ting Ye, Zehua Yan, Xinzhou Song, Baofeng Li, Lei Lin, Fangyou Cheng, Fan BMC Microbiol Research BACKGROUND: Mounting evidence indicates that the gut microbiome (GMB) plays an essential role in kidney stone (KS) formation. In this study, we conducted a systematic review and meta-analysis to compare the composition of gut microbiota in kidney stone patients and healthy individuals, and further understand the role of gut microbiota in nephrolithiasis. RESULTS: Six databases were searched to find taxonomy-based comparison studies on the GMB until September 2022. Meta-analyses were performed using RevMan 5.3 to estimate the overall relative abundance of gut microbiota in KS patients and healthy subjects. Eight studies were included with 356 nephrolithiasis patients and 347 healthy subjects. The meta-analysis suggested that KS patients had a higher abundance of Bacteroides (35.11% vs 21.25%, Z = 3.56, P = 0.0004) and Escherichia_Shigella (4.39% vs 1.78%, Z = 3.23, P = 0.001), and a lower abundance of Prevotella_9 (8.41% vs 10.65%, Z = 4.49, P < 0.00001). Qualitative analysis revealed that beta-diversity was different between the two groups (P < 0.05); Ten taxa (Bacteroides, Phascolarctobacterium, Faecalibacterium, Flavobacterium, Akkermansia, Lactobacillus, Escherichia coli, Rhodobacter and Gordonia) helped the detection of kidney stones (P < 0.05); Genes or protein families of the GMB involved in oxalate degradation, glycan synthesis, and energy metabolism were altered in patients (P < 0.05). CONCLUSIONS: There is a characteristic gut microbiota dysbiosis in kidney stone patients. Individualized therapies like microbial supplementation, probiotic or synbiotic preparations and adjusted diet patterns based on individual gut microbial characteristics of patients may be more effective in preventing stone formation and recurrence. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-023-02891-0. BioMed Central 2023-05-19 /pmc/articles/PMC10197343/ /pubmed/37208622 http://dx.doi.org/10.1186/s12866-023-02891-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yuan, Tianhui Xia, Yuqi Li, Bojun Yu, Weimin Rao, Ting Ye, Zehua Yan, Xinzhou Song, Baofeng Li, Lei Lin, Fangyou Cheng, Fan Gut microbiota in patients with kidney stones: a systematic review and meta-analysis |
title | Gut microbiota in patients with kidney stones: a systematic review and meta-analysis |
title_full | Gut microbiota in patients with kidney stones: a systematic review and meta-analysis |
title_fullStr | Gut microbiota in patients with kidney stones: a systematic review and meta-analysis |
title_full_unstemmed | Gut microbiota in patients with kidney stones: a systematic review and meta-analysis |
title_short | Gut microbiota in patients with kidney stones: a systematic review and meta-analysis |
title_sort | gut microbiota in patients with kidney stones: a systematic review and meta-analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197343/ https://www.ncbi.nlm.nih.gov/pubmed/37208622 http://dx.doi.org/10.1186/s12866-023-02891-0 |
work_keys_str_mv | AT yuantianhui gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT xiayuqi gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT libojun gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT yuweimin gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT raoting gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT yezehua gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT yanxinzhou gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT songbaofeng gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT lilei gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT linfangyou gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis AT chengfan gutmicrobiotainpatientswithkidneystonesasystematicreviewandmetaanalysis |