False hyperthyroidism caused by interference in immunoassays

OBJECTIVES: Immunoassays used to assess thyroid function are vulnerable to different types of interference that may affect clinical decision-making. CASE PRESENTATION: We report the case of a 37-year-old woman who developed iatrogenic hypothyroidism after having received radioiode therapy who visite...

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Detalles Bibliográficos
Autores principales: Jiménez García, Clara, Ortega Fernández, Piedad, Torregrosa Quesada, María Eugenia, González Bueno, Victoria, Botella Belda, María Teresa, Guerra, Rocío Alfayate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197363/
https://www.ncbi.nlm.nih.gov/pubmed/37359205
http://dx.doi.org/10.1515/almed-2020-0097
Descripción
Sumario:OBJECTIVES: Immunoassays used to assess thyroid function are vulnerable to different types of interference that may affect clinical decision-making. CASE PRESENTATION: We report the case of a 37-year-old woman who developed iatrogenic hypothyroidism after having received radioiode therapy who visited our hospital for her annual checkup. The patient was asymptomatic, without signs suggestive of thyroid disease. However, laboratory analysis proved otherwise: thyrotropin (TSH) 7.75 mU/L, thyroxine (FT4) >7.7 ng/dL. CONCLUSIONS: The inconsistency between her clinical symptoms and the biochemistry data raised the possibility of a methodological interference. A thorough evaluation of the main causes of interference was conducted in the laboratory to exclude the presence of interference in TSH and FT4. Finally, different interfering agents were identified, which affected free thyroid hormone and TSH determination.

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