Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

Dopa-responsive dystonia (DRD) and Parkinson’s disease (PD) are movement disorders caused by the dysfunction of nigrostriatal dopaminergic neurons. Identifying druggable pathways and biomarkers for guiding therapies is crucial due to the debilitating nature of these disorders. Recent genetic studies...

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Detalles Bibliográficos
Autores principales: Cronin, Shane J. F., Yu, Weonjin, Hale, Ashley, Licht-Mayer, Simon, Crabtree, Mark J, Korecka, Joanna A., Tretiakov, Evgenii O., Sealey-Cardona, Marco, Somlyay, Mate, Onji, Masahiro, An, Meilin, Fox, Jesse D., Turnes, Bruna Lenfers, Gomez-Diaz, Carlos, da Luz Scheffer, Débora, Cikes, Domagoj, Nagy, Vanja, Weidinger, Adelheid, Wolf, Alexandra, Reither, Harald, Chabloz, Antoine, Kavirayani, Anoop, Rao, Shuan, Andrews, Nick, Latremoliere, Alban, Costigan, Michael, Douglas, Gillian, Freitas, Fernando Cini, Pifl, Christian, Walz, Roger, Konrat, Robert, Mahad, Don J., Koslov, Andrey V., Latini, Alexandra, Isacson, Ole, Harkany, Tibor, Hallett, Penelope J., Bagby, Stefan, Woolf, Clifford J., Channon, Keith M., Je, Hyunsoo Shawn, Penninger, Josef M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197517/
https://www.ncbi.nlm.nih.gov/pubmed/37214873
http://dx.doi.org/10.1101/2023.05.08.539795

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