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The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-Lck interactions

CD4(+) T cell activation is driven by 5-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 complex...

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Detalles Bibliográficos
Autores principales:	Lee, Mark S., Tuohy, Peter J., Kim, Caleb Y., Yost, Philip P., Lichauco, Katrina, Parrish, Heather L., Van Doorslaer, Koenraad, Kuhns, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197521/ https://www.ncbi.nlm.nih.gov/pubmed/37214965 http://dx.doi.org/10.1101/2023.05.05.539613

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