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Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer

Thioredoxin Reductase (TrxR) is a key enzyme in reactive oxygen species (ROS) detoxification and in redox regulation. Because cancer cells produce increased steady-state levels of ROS (i.e., superoxide and hydrogen peroxide), TrxR is viable target in clinical trials using the anti-rheumatic drug, au...

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Detalles Bibliográficos
Autores principales:	Johnson, Spenser S., Liu, Dijie, Ewald, Jordan T., Robles-Planells, Claudia, Bayanbold, Khaliunaa, Wels, Brian R., Solst, Shane R., O’Dorisio, M. Sue, Allen, Bryan G., Menda, Yusuf, Spitz, Douglas R., Fath, Melissa A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197533/ https://www.ncbi.nlm.nih.gov/pubmed/37215042 http://dx.doi.org/10.1101/2023.05.07.539772

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