Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disorder caused by a CAG-polyglutamine repeat expansion. SCA7 patients display a striking loss of Purkinje cell (PC) neurons with disease progression; however, PCs are rare, making them difficult to characterize. We developed a P...

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Detalles Bibliográficos
Autores principales: Bartelt, Luke C., Switonski, Pawel M., Adamek, Grażyna, Carvalho, Juliana, Duvick, Lisa A., Jarrah, Sabrina I., McLoughlin, Hayley S., Scoles, Daniel R., Pulst, Stefan M., Orr, Harry T., Hull, Court, Lowe, Craig B., La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197555/
https://www.ncbi.nlm.nih.gov/pubmed/37214832
http://dx.doi.org/10.1101/2023.03.19.533345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197555/
https://www.ncbi.nlm.nih.gov/pubmed/37214832
http://dx.doi.org/10.1101/2023.03.19.533345

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