Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Tumor angiogenesis is a cancer hallmark, and its therapeutic inhibition has provided meaningful, albeit limited, clinical benefit. While anti-angiogenesis inhibitors deprive the tumor of oxygen and essential nutrients, cancer cells activate metabolic adaptations to diminish therapeutic response. Des...

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Detalles Bibliográficos
Autores principales: Khadka, Sunada, Lin, Yu-Hsi, Ackroyd, Jeffrey, Chen, Yi-An, Sheng, Yanghui, Qian, Wubin, Guo, Sheng, Chen, Yining, Behr, Eliot, Barekatain, Yasaman, Uddin, Nasir, Arthur, Kenisha, Yan, Victoria, Hsu, Wen-Hao, Chang, Qing, Poral, Anton, Tran, Theresa, Chaurasia, Surendra, Georgiou, Dimitra K., Asara, John M., Barthel, Floris P., Millward, Steve W., DePinho, Ronald A., Muller, Florian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197573/
https://www.ncbi.nlm.nih.gov/pubmed/37214825
http://dx.doi.org/10.1101/2023.05.07.539744

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