RNase H genes cause distinct impacts on RNA:DNA hybrid formation and mutagenesis genome-wide

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RNA:DNA hybrids such as R-loops affect genome integrity and DNA replication fork progression. The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases H to mitigating the negative effects of hybrids, remain unknown. Here, we inve...

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Detalles Bibliográficos
Autores principales: Schroeder, Jeremy W., Hurto, Rebecca L., Randall, Justin R., Wozniak, Katherine J., Timko, Taylor A., Nye, Taylor M., Wang, Jue D., Freddolino, Peter L., Simmons, Lyle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197577/
https://www.ncbi.nlm.nih.gov/pubmed/37214986
http://dx.doi.org/10.1101/2023.05.08.539860
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