Cargando…
Simultaneous enhancement of multiple functional properties using evolution-informed protein design
Designing optimized proteins is important for a range of practical applications. Protein design is a rapidly developing field that would benefit from approaches that enable many changes in the amino acid primary sequence, rather than a small number of mutations, while maintaining structure and enhan...
Autores principales: | Fram, Benjamin, Truebridge, Ian, Su, Yang, Riesselman, Adam J., Ingraham, John B., Passera, Alessandro, Napier, Eve, Thadani, Nicole N., Lim, Samuel, Roberts, Kristen, Kaur, Gurleen, Stiffler, Michael, Marks, Debora S., Bahl, Christopher D., Khan, Amir R., Sander, Chris, Gauthier, Nicholas P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197589/ https://www.ncbi.nlm.nih.gov/pubmed/37214973 http://dx.doi.org/10.1101/2023.05.09.539914 |
Ejemplares similares
-
Inferring protein 3D structure from deep mutation scans
por: Rollins, Nathan J., et al.
Publicado: (2019) -
Learning from prepandemic data to forecast viral escape
por: Thadani, Nicole N., et al.
Publicado: (2023) -
Protein design and variant prediction using autoregressive generative models
por: Shin, Jung-Eun, et al.
Publicado: (2021) -
The EVcouplings Python framework for coevolutionary sequence analysis
por: Hopf, Thomas A, et al.
Publicado: (2019) -
mRNA turnover rate limits siRNA and microRNA efficacy
por: Larsson, Erik, et al.
Publicado: (2010)