Development and Biophysical Characterization of a Humanized FSH–Blocking Monoclonal Antibody Therapeutic Formulated at an Ultra–High Concentration

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Highly concentrated antibody formulations are oftentimes required for subcutaneous, self-administered biologics. Here, we report the creation of a unique formulation for our first–in–class FSH–blocking humanized antibody, MS-Hu6, which we propose to move to the clinic for osteoporosis, obesity, and...

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Detalles Bibliográficos
Autores principales: Rojekar, Satish, Pallapati, Anusha R., Gimenez–Roig, Judit, Korkmaz, Funda, Sultana, Farhath, Sant, Damini, Haeck, Clement, Macdonald, Anne, Kim, Se-Min, Rosen, Clifford J., Barak, Orly, Meseck, Marcia, Caminis, John, Lizneva, Daria, Yuen, Tony, Zaidi, Mone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197643/
https://www.ncbi.nlm.nih.gov/pubmed/37214886
http://dx.doi.org/10.1101/2023.05.11.540323
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