Elevated nuclear TDP-43 induces constitutive exon skipping

Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate in vitro and in vivo model system...

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Detalles Bibliográficos
Autores principales: Carmen-Orozco, Rogger P., Tsao, William, Ye, Yingzhi, Sinha, Irika R., Chang, Koping, Trinh, Vickie, Chung, William, Bowden, Kyra, Troncoso, Juan C., Blackshaw, Seth, Hayes, Lindsey R., Sun, Shuying, Wong, Philip C., Ling, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197708/
https://www.ncbi.nlm.nih.gov/pubmed/37215013
http://dx.doi.org/10.1101/2023.05.11.540291

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