Evidence of Bisphosphonate-Conjugated Sitafloxacin Eradication of Established Methicillin-Resistant S. aureus Infection with Osseointegration in Murine Models of Implant-Associated Osteomyelitis

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Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve “target-and-release” drug delivery proximal to the bone i...

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Detalles Bibliográficos
Autores principales: Xie, Chao, Ren, Youliang, Weeks, Jason, Xue, Thomas, Rainbolt, Joshua, Bentley, Karen de Mesy, Shu, Ye, Liu, Yuting, Masters, Elysia, Cherian, Philip, McKenna, Charles, Neighbors, Jeffrey, Ebetino, Frank, Schwarz, Edward, Sun, Shuting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197753/
https://www.ncbi.nlm.nih.gov/pubmed/37214929
http://dx.doi.org/10.21203/rs.3.rs-2856287/v1
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