Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy

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BACKGROUND: Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration, and epileptogenesis as a consequence. Medical countermeas...

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Detalles Bibliográficos
Autores principales: Vasanthi, Suraj S., Rao, Nikhil S., Samidurai, Manikandan, Massey, Nyzil, Meyer, Christina, Gage, Meghan, Kharate, Mihir, Almanza, Aida, Wachter, Logan, Mafuta, Candide, Trevino, Lily, Carlo, Adriana M, Bryant, Elijah, Corson, Brooke E., Wohlgemuth, Morgan, Ostrander, Morgan, Wang, Chong, Thippeswamy, Thimmasettappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197763/
https://www.ncbi.nlm.nih.gov/pubmed/37214912
http://dx.doi.org/10.21203/rs.3.rs-2883247/v1

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