Effects of intranasal dantrolene nanoparticles on brain concentration and behavior in PS19 tau transgenic mice

BACKGROUND: Repurposing dantrolene as a potential disease-modifying treatment for Alzheimer’s disease has been shown to be effective in amyloid transgenic mouse models but has not been examined in a model of tauopathy. OBJECTIVE: The effects of a nanoparticle intranasal formulation, the Eagle Resear...

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Detalles Bibliográficos
Autores principales: Vera, Robert, Hong, Nicholas, Jiang, Bailin, Liang, Grace, Eckenhoff, Maryellen F, Kincaid, Halle J, Browne, Veron, Chellaraj, Vinolia, Gisewhite, Douglas, Greenberg, Michael, Ranjan, Sudhir, Zhu, Gaozhong, Wei, Huafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197765/
https://www.ncbi.nlm.nih.gov/pubmed/37214948
http://dx.doi.org/10.21203/rs.3.rs-2802620/v1

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