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SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole

Starting from compound 5 (CCF0058981), a structure-based optimization of the P1 subsite was performed against the severe acute respiratory syndrome coronavirus (SARS-CoV-2) main protease (3CL(pro)). Inhibitor 5 and the compounds disclosed bind to 3CL(pro) using a non-covalent mode of action that uti...

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Detalles Bibliográficos
Autores principales:	Hooper, Alice, Macdonald, Jonathan D., Reilly, Brenna, Maw, Joshua, Wirrick, Aidan P, Han, Sang Hoon, Lindsey, A. Abigail, Rico, Emma G, Romigh, Todd, Goins, Christopher M, Wang, Nancy S, Stauffer, Shaun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197776/ https://www.ncbi.nlm.nih.gov/pubmed/37214977 http://dx.doi.org/10.21203/rs.3.rs-2880312/v1

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