Comparison of two doses of leucovorin in severe low-dose methotrexate toxicity – a randomized controlled trial

BACKGROUND: Leucovorin (folinic acid) is a commonly used antidote for severe toxicity with low-dose methotrexate, but its optimum dose is unclear, varying from 15 to 25 mg every 6-h. METHODS: Open-label RCT included patients with severe low-dose (≤ 50 mg/week) methotrexate toxicity defined as WBC ≤ ...

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Detalles Bibliográficos
Autores principales: Bhargava, Mudit, Kopp, Chirag Rajkumar, Naidu, Shankar, Dhibar, Deba Prasad, Saroch, Atul, Khadwal, Alka, Narang, Tarun, Jain, Siddharth, Khullar, Aastha, Leishangthem, Bidya, Sharma, Aman, Kumar, Susheel, Sharma, Shefali, Jain, Sanjay, Dhir, Varun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197821/
https://www.ncbi.nlm.nih.gov/pubmed/37208770
http://dx.doi.org/10.1186/s13075-023-03054-2

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