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Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)

The aim of the present review was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) accumulation and toxicity in the host, and to reveal potential the mediatory effects of the gut microbiota on AGE-related health effects. The existing...

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Autores principales: Aschner, Michael, Skalny, Anatoly V., Gritsenko, Viktor A., Kartashova, Olga L., Santamaria, Abel, Rocha, Joao B.T., Spandidos, Demetrios A., Zaitseva, Irina P., Tsatsakis, Aristidis, Tinkov, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198061/
https://www.ncbi.nlm.nih.gov/pubmed/37052251
http://dx.doi.org/10.3892/ijmm.2023.5247
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author Aschner, Michael
Skalny, Anatoly V.
Gritsenko, Viktor A.
Kartashova, Olga L.
Santamaria, Abel
Rocha, Joao B.T.
Spandidos, Demetrios A.
Zaitseva, Irina P.
Tsatsakis, Aristidis
Tinkov, Alexey A.
author_facet Aschner, Michael
Skalny, Anatoly V.
Gritsenko, Viktor A.
Kartashova, Olga L.
Santamaria, Abel
Rocha, Joao B.T.
Spandidos, Demetrios A.
Zaitseva, Irina P.
Tsatsakis, Aristidis
Tinkov, Alexey A.
author_sort Aschner, Michael
collection PubMed
description The aim of the present review was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) accumulation and toxicity in the host, and to reveal potential the mediatory effects of the gut microbiota on AGE-related health effects. The existing data demonstrate that dietary AGEs can have a significant impact on the richness and diversity of the gut microbiota, although the particular effect is dependent on the type of species, as well as the exposure dose. In addition, the gut microbiota may metabolize dietary AGEs. It has been also demonstrated that the characteristics of the gut microbiota, including its richness and relative abundance of certain taxa, is tightly associated with AGE accumulation in the host organism. In turn, a bilateral interplay between AGE toxicity and the modulation of the gut microbiota may contribute to pathogenesis of ageing and diabetes-associated diseases. Bacterial endotoxin lipopolysaccharide appears as the molecule that mediates the interactions between the gut microbiota and AGE toxicity, specifically via the modulation of the receptor for AGE signaling. Therefore, it is proposed that the modulation of the gut microbiota using probiotics or other dietary interventions may have a significant impact on AGE-induced glycative stress and systemic inflammation.
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spelling pubmed-101980612023-05-20 Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review) Aschner, Michael Skalny, Anatoly V. Gritsenko, Viktor A. Kartashova, Olga L. Santamaria, Abel Rocha, Joao B.T. Spandidos, Demetrios A. Zaitseva, Irina P. Tsatsakis, Aristidis Tinkov, Alexey A. Int J Mol Med Articles The aim of the present review was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) accumulation and toxicity in the host, and to reveal potential the mediatory effects of the gut microbiota on AGE-related health effects. The existing data demonstrate that dietary AGEs can have a significant impact on the richness and diversity of the gut microbiota, although the particular effect is dependent on the type of species, as well as the exposure dose. In addition, the gut microbiota may metabolize dietary AGEs. It has been also demonstrated that the characteristics of the gut microbiota, including its richness and relative abundance of certain taxa, is tightly associated with AGE accumulation in the host organism. In turn, a bilateral interplay between AGE toxicity and the modulation of the gut microbiota may contribute to pathogenesis of ageing and diabetes-associated diseases. Bacterial endotoxin lipopolysaccharide appears as the molecule that mediates the interactions between the gut microbiota and AGE toxicity, specifically via the modulation of the receptor for AGE signaling. Therefore, it is proposed that the modulation of the gut microbiota using probiotics or other dietary interventions may have a significant impact on AGE-induced glycative stress and systemic inflammation. D.A. Spandidos 2023-04-11 /pmc/articles/PMC10198061/ /pubmed/37052251 http://dx.doi.org/10.3892/ijmm.2023.5247 Text en Copyright: © Aschner et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Aschner, Michael
Skalny, Anatoly V.
Gritsenko, Viktor A.
Kartashova, Olga L.
Santamaria, Abel
Rocha, Joao B.T.
Spandidos, Demetrios A.
Zaitseva, Irina P.
Tsatsakis, Aristidis
Tinkov, Alexey A.
Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)
title Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)
title_full Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)
title_fullStr Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)
title_full_unstemmed Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)
title_short Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)
title_sort role of gut microbiota in the modulation of the health effects of advanced glycation end-products (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198061/
https://www.ncbi.nlm.nih.gov/pubmed/37052251
http://dx.doi.org/10.3892/ijmm.2023.5247
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