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Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature

BACKGROUND: Papillary thyroid cancer (PTC) is one of the well-differentiated thyroid tumors. Cutaneous metastasis from differentiated thyroid cancers occurs in < 1% of primary thyroid carcinomas but produces the worst survival prognosis. The multi-targeting tyrosine kinase inhibitor anlotinib has...

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Autores principales: Zhang, Li-Yong, Cai, Shao-Jun, Liang, Bo-Yan, Yan, Shou-Yi, Wang, Bo, Li, Meng-Yao, Zhao, Wen-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198115/
https://www.ncbi.nlm.nih.gov/pubmed/37214573
http://dx.doi.org/10.12998/wjcc.v11.i12.2839
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author Zhang, Li-Yong
Cai, Shao-Jun
Liang, Bo-Yan
Yan, Shou-Yi
Wang, Bo
Li, Meng-Yao
Zhao, Wen-Xin
author_facet Zhang, Li-Yong
Cai, Shao-Jun
Liang, Bo-Yan
Yan, Shou-Yi
Wang, Bo
Li, Meng-Yao
Zhao, Wen-Xin
author_sort Zhang, Li-Yong
collection PubMed
description BACKGROUND: Papillary thyroid cancer (PTC) is one of the well-differentiated thyroid tumors. Cutaneous metastasis from differentiated thyroid cancers occurs in < 1% of primary thyroid carcinomas but produces the worst survival prognosis. The multi-targeting tyrosine kinase inhibitor anlotinib has been approved to treat refractory advanced non-small-cell lung cancer as well as advanced soft-tissue and clear cell sarcomas in China. CASE SUMMARY: In a patient with scalp metastasis caused by PTC, thyroid and skull metastasis tumor sizes were significantly reduced after a trial of neoadjuvant anlotinib therapy for 3 cycles. Anlotinib maintenance medication after thyroidectomy further reduced the metastatic skull tumor size thereby preventing the requirement for craniotomy. CONCLUSION: The outcome of the present trial confirmed the potential of anlotinib therapy to treat scalp metastasis induced by PTC and point the way for the treatment of similar diseases in the future.
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spelling pubmed-101981152023-05-20 Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature Zhang, Li-Yong Cai, Shao-Jun Liang, Bo-Yan Yan, Shou-Yi Wang, Bo Li, Meng-Yao Zhao, Wen-Xin World J Clin Cases Case Report BACKGROUND: Papillary thyroid cancer (PTC) is one of the well-differentiated thyroid tumors. Cutaneous metastasis from differentiated thyroid cancers occurs in < 1% of primary thyroid carcinomas but produces the worst survival prognosis. The multi-targeting tyrosine kinase inhibitor anlotinib has been approved to treat refractory advanced non-small-cell lung cancer as well as advanced soft-tissue and clear cell sarcomas in China. CASE SUMMARY: In a patient with scalp metastasis caused by PTC, thyroid and skull metastasis tumor sizes were significantly reduced after a trial of neoadjuvant anlotinib therapy for 3 cycles. Anlotinib maintenance medication after thyroidectomy further reduced the metastatic skull tumor size thereby preventing the requirement for craniotomy. CONCLUSION: The outcome of the present trial confirmed the potential of anlotinib therapy to treat scalp metastasis induced by PTC and point the way for the treatment of similar diseases in the future. Baishideng Publishing Group Inc 2023-04-26 2023-04-26 /pmc/articles/PMC10198115/ /pubmed/37214573 http://dx.doi.org/10.12998/wjcc.v11.i12.2839 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Zhang, Li-Yong
Cai, Shao-Jun
Liang, Bo-Yan
Yan, Shou-Yi
Wang, Bo
Li, Meng-Yao
Zhao, Wen-Xin
Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
title Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
title_full Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
title_fullStr Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
title_full_unstemmed Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
title_short Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
title_sort efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198115/
https://www.ncbi.nlm.nih.gov/pubmed/37214573
http://dx.doi.org/10.12998/wjcc.v11.i12.2839
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