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Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study

This study aimed to investigate the possible association between nasopharyngeal carcinoma (NPC) and following open angle glaucoma (OAG). A retrospective research applying the National Health Insurance Research Database (NHIRD) of Taiwan was conducted with a follow up period from January 1, 2000 to D...

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Autores principales: Lu, Wei-Yang, Lin, Chiao-Wen, Hsin, Chung-Han, Lee, Chia-Yi, Huang, Jing-Yang, Yang, Shun-Fa, Lin, Hung-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198144/
https://www.ncbi.nlm.nih.gov/pubmed/37213671
http://dx.doi.org/10.7150/ijms.80837
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author Lu, Wei-Yang
Lin, Chiao-Wen
Hsin, Chung-Han
Lee, Chia-Yi
Huang, Jing-Yang
Yang, Shun-Fa
Lin, Hung-Yu
author_facet Lu, Wei-Yang
Lin, Chiao-Wen
Hsin, Chung-Han
Lee, Chia-Yi
Huang, Jing-Yang
Yang, Shun-Fa
Lin, Hung-Yu
author_sort Lu, Wei-Yang
collection PubMed
description This study aimed to investigate the possible association between nasopharyngeal carcinoma (NPC) and following open angle glaucoma (OAG). A retrospective research applying the National Health Insurance Research Database (NHIRD) of Taiwan was conducted with a follow up period from January 1, 2000 to December 31, 2016. There were 4184 and 16736 participants that selected and categorized into the NPC and non-NPC groups after exclusion. The major outcome of our study was the development of OAG according to diagnostic codes, exam and managements. The Cox proportional hazard regression was employed to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of OAG between the two groups. In this study, a numbers of 151 and 513 OAG episodes occurred in the NPC and non-NPC groups and the NPC population showed a significantly higher incidence of OAG compared to the non-NPC population in multivariable analysis (aHR: 1.293, 95% CI: 1.077-1.551, p = 0.0057). Besides, the cumulative probability of OAG was significantly higher in the NPC group than that in the non-NPC population (p = 0.0041). About other risk factor for OAG, age older than 40 years old, diabetes mellitus and persistent steroid usage were related to OAG occurrence (all p < 0.05). In conclusion, the NPC may be an independent risk factor of following OAG development.
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spelling pubmed-101981442023-05-20 Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study Lu, Wei-Yang Lin, Chiao-Wen Hsin, Chung-Han Lee, Chia-Yi Huang, Jing-Yang Yang, Shun-Fa Lin, Hung-Yu Int J Med Sci Research Paper This study aimed to investigate the possible association between nasopharyngeal carcinoma (NPC) and following open angle glaucoma (OAG). A retrospective research applying the National Health Insurance Research Database (NHIRD) of Taiwan was conducted with a follow up period from January 1, 2000 to December 31, 2016. There were 4184 and 16736 participants that selected and categorized into the NPC and non-NPC groups after exclusion. The major outcome of our study was the development of OAG according to diagnostic codes, exam and managements. The Cox proportional hazard regression was employed to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of OAG between the two groups. In this study, a numbers of 151 and 513 OAG episodes occurred in the NPC and non-NPC groups and the NPC population showed a significantly higher incidence of OAG compared to the non-NPC population in multivariable analysis (aHR: 1.293, 95% CI: 1.077-1.551, p = 0.0057). Besides, the cumulative probability of OAG was significantly higher in the NPC group than that in the non-NPC population (p = 0.0041). About other risk factor for OAG, age older than 40 years old, diabetes mellitus and persistent steroid usage were related to OAG occurrence (all p < 0.05). In conclusion, the NPC may be an independent risk factor of following OAG development. Ivyspring International Publisher 2023-04-17 /pmc/articles/PMC10198144/ /pubmed/37213671 http://dx.doi.org/10.7150/ijms.80837 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Lu, Wei-Yang
Lin, Chiao-Wen
Hsin, Chung-Han
Lee, Chia-Yi
Huang, Jing-Yang
Yang, Shun-Fa
Lin, Hung-Yu
Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study
title Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study
title_full Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study
title_fullStr Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study
title_full_unstemmed Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study
title_short Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study
title_sort association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198144/
https://www.ncbi.nlm.nih.gov/pubmed/37213671
http://dx.doi.org/10.7150/ijms.80837
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