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Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of triglycerides within the liver. However, whether the circulating levels of triglycerides and cholesterol transported in triglyceride-rich lipoproteins (remnant cholesterol, remnant-C) are related to th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198261/ https://www.ncbi.nlm.nih.gov/pubmed/37214248 http://dx.doi.org/10.3389/fendo.2023.1098078 |
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author | Cheng, Yiping Zhang, Qiang Li, Haizhen Zhou, Guangshuai Shi, Ping Zhang, Xu Guan, Liying Yan, Fang Xu, Chao |
author_facet | Cheng, Yiping Zhang, Qiang Li, Haizhen Zhou, Guangshuai Shi, Ping Zhang, Xu Guan, Liying Yan, Fang Xu, Chao |
author_sort | Cheng, Yiping |
collection | PubMed |
description | INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of triglycerides within the liver. However, whether the circulating levels of triglycerides and cholesterol transported in triglyceride-rich lipoproteins (remnant cholesterol, remnant-C) are related to the occurrence of NAFLD has not yet been studied. This study aims to assess the association of triglycerides and remnant-C with NAFLD in a Chinese cohort of middle aged and elderly individuals. METHODS: All subjects in the current study are from the 13,876 individuals who recruited in the Shandong cohort of the REACTION study. We included 6,634 participants who had more than one visit during the study period with an average follow-up time of 43.34 months. The association between lipid concentrations and incident NAFLD were evaluated by unadjusted and adjusted Cox proportional hazard models. The potential confounders were adjusted in the models including age, sex, hip circumference (HC), body mass index (BMI), systolic blood pressure, diastolic blood pressure, fasting plasma glucose (FPG), diabetes status and cardiovascular disease (CVD) status. RESULTS: In multivariable-adjusted Cox proportional hazard model analyses, triglycerides (hazard ratio[HR], 95% confidence interval [CI]:1.080,1.047-1.113;p<0.001), high-density lipoprotein cholesterol (HDL-C) (HR, 95% CI: 0.571,0.487-0.670; p<0.001), and remnant-C (HR, 95% CI: 1.143,1.052-1.242; p=0.002), but not total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C), were associated with incident NAFLD. Atherogenic dyslipidemia (triglycerides>1.69 mmol/L, HDL-C<1.03 mmol/L in men or<1.29 mmol/L in women) was also associated with NAFLD (HR, 95% CI: 1.343,1.177-1.533; p<0.001). Remnant-C levels were higher in females than in males and increased with increasing BMI and in participants with diabetes and CVD compared with those without diabetes or CVD. After adjusting for other factors in the Cox regression models, we found that serum levels of TG and remnant-C, but not TC or LDL-C, were associated with NAFLD outcomes in women group, non-cardiovascular disease status, non-diabetes status and middle BMI categories (24 to 28 kg/m2). DISCUSSION: In the middle aged and elderly subset of the Chinese population, especially those who were women, non-CVD status, non-diabetes status and middle BMI status (24 to 28 kg/m2), levels of triglycerides and remnant-C, but not TC or LDL-C, were associated with NAFLD outcomes independent of other risk factors. |
format | Online Article Text |
id | pubmed-10198261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101982612023-05-20 Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease Cheng, Yiping Zhang, Qiang Li, Haizhen Zhou, Guangshuai Shi, Ping Zhang, Xu Guan, Liying Yan, Fang Xu, Chao Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of triglycerides within the liver. However, whether the circulating levels of triglycerides and cholesterol transported in triglyceride-rich lipoproteins (remnant cholesterol, remnant-C) are related to the occurrence of NAFLD has not yet been studied. This study aims to assess the association of triglycerides and remnant-C with NAFLD in a Chinese cohort of middle aged and elderly individuals. METHODS: All subjects in the current study are from the 13,876 individuals who recruited in the Shandong cohort of the REACTION study. We included 6,634 participants who had more than one visit during the study period with an average follow-up time of 43.34 months. The association between lipid concentrations and incident NAFLD were evaluated by unadjusted and adjusted Cox proportional hazard models. The potential confounders were adjusted in the models including age, sex, hip circumference (HC), body mass index (BMI), systolic blood pressure, diastolic blood pressure, fasting plasma glucose (FPG), diabetes status and cardiovascular disease (CVD) status. RESULTS: In multivariable-adjusted Cox proportional hazard model analyses, triglycerides (hazard ratio[HR], 95% confidence interval [CI]:1.080,1.047-1.113;p<0.001), high-density lipoprotein cholesterol (HDL-C) (HR, 95% CI: 0.571,0.487-0.670; p<0.001), and remnant-C (HR, 95% CI: 1.143,1.052-1.242; p=0.002), but not total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C), were associated with incident NAFLD. Atherogenic dyslipidemia (triglycerides>1.69 mmol/L, HDL-C<1.03 mmol/L in men or<1.29 mmol/L in women) was also associated with NAFLD (HR, 95% CI: 1.343,1.177-1.533; p<0.001). Remnant-C levels were higher in females than in males and increased with increasing BMI and in participants with diabetes and CVD compared with those without diabetes or CVD. After adjusting for other factors in the Cox regression models, we found that serum levels of TG and remnant-C, but not TC or LDL-C, were associated with NAFLD outcomes in women group, non-cardiovascular disease status, non-diabetes status and middle BMI categories (24 to 28 kg/m2). DISCUSSION: In the middle aged and elderly subset of the Chinese population, especially those who were women, non-CVD status, non-diabetes status and middle BMI status (24 to 28 kg/m2), levels of triglycerides and remnant-C, but not TC or LDL-C, were associated with NAFLD outcomes independent of other risk factors. Frontiers Media S.A. 2023-05-05 /pmc/articles/PMC10198261/ /pubmed/37214248 http://dx.doi.org/10.3389/fendo.2023.1098078 Text en Copyright © 2023 Cheng, Zhang, Li, Zhou, Shi, Zhang, Guan, Yan and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Cheng, Yiping Zhang, Qiang Li, Haizhen Zhou, Guangshuai Shi, Ping Zhang, Xu Guan, Liying Yan, Fang Xu, Chao Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease |
title | Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease |
title_full | Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease |
title_fullStr | Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease |
title_full_unstemmed | Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease |
title_short | Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease |
title_sort | remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198261/ https://www.ncbi.nlm.nih.gov/pubmed/37214248 http://dx.doi.org/10.3389/fendo.2023.1098078 |
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