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The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation

BACKGROUND: Acute appendicitis (AA) is one of the most common causes of abdominal pain in patients presenting to the emergency department with abdominal pain, and despite developments in radiological imaging for its diagnosis, researchers are still in pursuit of a simpler, cheaper, and safer biomark...

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Autores principales: Çekmen, Bora, Bildik, Büşra, Atiş, Şeref Emre, Güven, Hüseyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198349/
https://www.ncbi.nlm.nih.gov/pubmed/36588506
http://dx.doi.org/10.14744/tjtes.2022.56570
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author Çekmen, Bora
Bildik, Büşra
Atiş, Şeref Emre
Güven, Hüseyin
author_facet Çekmen, Bora
Bildik, Büşra
Atiş, Şeref Emre
Güven, Hüseyin
author_sort Çekmen, Bora
collection PubMed
description BACKGROUND: Acute appendicitis (AA) is one of the most common causes of abdominal pain in patients presenting to the emergency department with abdominal pain, and despite developments in radiological imaging for its diagnosis, researchers are still in pursuit of a simpler, cheaper, and safer biomarker. Our study investigated the usability of the neutrophil–albumin ratio, a biomarker that predicts prognosis in cases with severe inflammation, in diagnosing AA and anticipating perforation. METHODS: Our study is a retrospective and cross-sectional study. The study was conducted with patients who presented to the emergency department between January 2018 and December 2020 and were hospitalized with a preliminary diagnosis of AA. The cases were first divided into two groups as “Not appendicitis” and “AA,” and then the patients with “AA” were divided into two subgroups as “Perforated” and “Non-perforated.” The demographic data of the patients, their symptoms, physical examination findings, and the decision-making process for surgery were noted. The neutrophil count and albumin levels detected in the blood samples obtained at the time of admission to the emergency department were noted. Afterward, the neutrophil-albumin ratio (NAR) was calculated and the cutoff level was determined to predict the diagnosis of AA and the development of perforation. RESULTS: The rate of complaints of pain in the periumbilical region was significantly higher in the patient group without AA compared to the patients in the AA group (70.6% and 40.3%, p=0.034). Although the leukocyte count, neutrophil count and percentage, and NAR were significantly higher in the AA group, the lymphocyte count was found to be significantly lower (p=0.005). However, no significant correlation was found between the NAR and the development of perforation (p=0.697). CONCLUSION: The NAR is useful for the diagnosis of AA. Nevertheless, it is not a sufficient biomarker for detecting perforation.
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spelling pubmed-101983492023-06-02 The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation Çekmen, Bora Bildik, Büşra Atiş, Şeref Emre Güven, Hüseyin Ulus Travma Acil Cerrahi Derg Original Article BACKGROUND: Acute appendicitis (AA) is one of the most common causes of abdominal pain in patients presenting to the emergency department with abdominal pain, and despite developments in radiological imaging for its diagnosis, researchers are still in pursuit of a simpler, cheaper, and safer biomarker. Our study investigated the usability of the neutrophil–albumin ratio, a biomarker that predicts prognosis in cases with severe inflammation, in diagnosing AA and anticipating perforation. METHODS: Our study is a retrospective and cross-sectional study. The study was conducted with patients who presented to the emergency department between January 2018 and December 2020 and were hospitalized with a preliminary diagnosis of AA. The cases were first divided into two groups as “Not appendicitis” and “AA,” and then the patients with “AA” were divided into two subgroups as “Perforated” and “Non-perforated.” The demographic data of the patients, their symptoms, physical examination findings, and the decision-making process for surgery were noted. The neutrophil count and albumin levels detected in the blood samples obtained at the time of admission to the emergency department were noted. Afterward, the neutrophil-albumin ratio (NAR) was calculated and the cutoff level was determined to predict the diagnosis of AA and the development of perforation. RESULTS: The rate of complaints of pain in the periumbilical region was significantly higher in the patient group without AA compared to the patients in the AA group (70.6% and 40.3%, p=0.034). Although the leukocyte count, neutrophil count and percentage, and NAR were significantly higher in the AA group, the lymphocyte count was found to be significantly lower (p=0.005). However, no significant correlation was found between the NAR and the development of perforation (p=0.697). CONCLUSION: The NAR is useful for the diagnosis of AA. Nevertheless, it is not a sufficient biomarker for detecting perforation. Kare Publishing 2023-01-03 /pmc/articles/PMC10198349/ /pubmed/36588506 http://dx.doi.org/10.14744/tjtes.2022.56570 Text en Copyright © 2023 Turkish Journal of Trauma and Emergency Surgery https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Article
Çekmen, Bora
Bildik, Büşra
Atiş, Şeref Emre
Güven, Hüseyin
The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation
title The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation
title_full The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation
title_fullStr The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation
title_full_unstemmed The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation
title_short The role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation
title_sort role of neutrophil–albumin ratio in the diagnosis of acute appendicitis and its efficacy in predicting perforation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198349/
https://www.ncbi.nlm.nih.gov/pubmed/36588506
http://dx.doi.org/10.14744/tjtes.2022.56570
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