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Long-term complications associated with the management of sinonasal malignancies: a single center experience

OBJECTIVE: The aim of this study was to review the long-term complications associated with treatment of patients with sinonasal malignancies (SNMs) and risk factors for these complications. METHODS: A retrospective analysis of all patients treated for SNMs at a tertiary care center between 2001 and...

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Detalles Bibliográficos
Autores principales: Levin, Einav G., Tzelnick, Sharon, Yaacobi, Daniel, Vainer, Igor, Mizrachi, Aviram, Popovtzer, Aron, Soudry, Ethan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198366/
https://www.ncbi.nlm.nih.gov/pubmed/37204845
http://dx.doi.org/10.14639/0392-100X-N1902
Descripción
Sumario:OBJECTIVE: The aim of this study was to review the long-term complications associated with treatment of patients with sinonasal malignancies (SNMs) and risk factors for these complications. METHODS: A retrospective analysis of all patients treated for SNMs at a tertiary care center between 2001 and 2018. A total of 77 patients were included. The primary outcome measure was post-treatment long-term complications. RESULTS: Overall, long-term complications were identified in 41 patients (53%), and the most common were sinonasal (22 patients, 29%) and orbital/ocular-related (18 patients, 23%). In a multivariate regression analysis, irradiation was the only significant predictor of long-term complications (p = 0.001, OR = 18.86, CI = 3.31-107.6). No association was observed between long-term complications and tumour stage, surgical modality, or radiation dose/modality. Mean radiation dose ≥ 50 Gy to the optic nerve was associated with grade ≥ 3 visual acuity impairment (100% vs 3%; p = 0.006). Radiation therapy for disease recurrence was associated with additional long-term complications (56% vs 11%; p = 0.04). CONCLUSIONS: Treatment of SNMs has substantial long-term complications, which are significantly associated with radiation therapy.