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Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study)

PURPOSE: Colorectal cancer (CRC) survivors often experience long-term symptoms after cancer treatments. But gastrointestinal (GI) symptom experiences are under-investigated in CRC survivors. We described persistent GI symptoms after cancer treatments in female CRC survivors and assessed GI symptoms’...

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Autores principales: Han, Claire J., Reding, Kerryn W., Kalady, Matthew F., Yung, Rachel, Greenlee, Heather, Paskett, Electra D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198480/
https://www.ncbi.nlm.nih.gov/pubmed/37205667
http://dx.doi.org/10.1371/journal.pone.0286058
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author Han, Claire J.
Reding, Kerryn W.
Kalady, Matthew F.
Yung, Rachel
Greenlee, Heather
Paskett, Electra D.
author_facet Han, Claire J.
Reding, Kerryn W.
Kalady, Matthew F.
Yung, Rachel
Greenlee, Heather
Paskett, Electra D.
author_sort Han, Claire J.
collection PubMed
description PURPOSE: Colorectal cancer (CRC) survivors often experience long-term symptoms after cancer treatments. But gastrointestinal (GI) symptom experiences are under-investigated in CRC survivors. We described persistent GI symptoms after cancer treatments in female CRC survivors and assessed GI symptoms’ risk and life-impact factors. METHODS: A cross-sectional study utilized data from the Women’s Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study that recruited postmenopausal women. Correlation analyses and multivariable linear regression models were used. RESULTS: CRC survivors after cancer treatments were included (N = 413, mean age 71.2 years old, mean time since diagnosis = 8.1 years). 81% of CRC survivors experienced persistent GI symptoms. Bloating/gas was the most prevalent (54.2%± 0.88) and severe GI symptom, followed by constipation (44.1%±1.06), diarrhea (33.4%±0.76), and abdominal/pelvic pain (28.6%±0.62). Significant risk factors for GI symptoms include time since cancer diagnosis (<5 years), advanced cancer stage, high psychological distress, poor dietary habits, and low physical activity. Fatigue and sleep disturbance were the most significant risk factors for long-term GI symptoms (β = 0.21, t = 3.557; β = 0.20, t = 3.336, respectively, Ps < .001). High severity of GI symptoms was positively associated with poor quality of life (QOL), increased daily life interferences (social and physical functions), and low body image satisfaction (Ps < .001). CONCLUSIONS: Women CRC survivors experience a high GI symptom burden, highlighting the need to inform policy and improve the QOL of cancer survivors. Our findings will aid in identifying those more vulnerable to symptoms, and inform future survivorship care interventions (i.e., community-based cancer symptom management) by considering multiple risk factors (e.g., psychological distress).
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spelling pubmed-101984802023-05-20 Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study) Han, Claire J. Reding, Kerryn W. Kalady, Matthew F. Yung, Rachel Greenlee, Heather Paskett, Electra D. PLoS One Research Article PURPOSE: Colorectal cancer (CRC) survivors often experience long-term symptoms after cancer treatments. But gastrointestinal (GI) symptom experiences are under-investigated in CRC survivors. We described persistent GI symptoms after cancer treatments in female CRC survivors and assessed GI symptoms’ risk and life-impact factors. METHODS: A cross-sectional study utilized data from the Women’s Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study that recruited postmenopausal women. Correlation analyses and multivariable linear regression models were used. RESULTS: CRC survivors after cancer treatments were included (N = 413, mean age 71.2 years old, mean time since diagnosis = 8.1 years). 81% of CRC survivors experienced persistent GI symptoms. Bloating/gas was the most prevalent (54.2%± 0.88) and severe GI symptom, followed by constipation (44.1%±1.06), diarrhea (33.4%±0.76), and abdominal/pelvic pain (28.6%±0.62). Significant risk factors for GI symptoms include time since cancer diagnosis (<5 years), advanced cancer stage, high psychological distress, poor dietary habits, and low physical activity. Fatigue and sleep disturbance were the most significant risk factors for long-term GI symptoms (β = 0.21, t = 3.557; β = 0.20, t = 3.336, respectively, Ps < .001). High severity of GI symptoms was positively associated with poor quality of life (QOL), increased daily life interferences (social and physical functions), and low body image satisfaction (Ps < .001). CONCLUSIONS: Women CRC survivors experience a high GI symptom burden, highlighting the need to inform policy and improve the QOL of cancer survivors. Our findings will aid in identifying those more vulnerable to symptoms, and inform future survivorship care interventions (i.e., community-based cancer symptom management) by considering multiple risk factors (e.g., psychological distress). Public Library of Science 2023-05-19 /pmc/articles/PMC10198480/ /pubmed/37205667 http://dx.doi.org/10.1371/journal.pone.0286058 Text en © 2023 Han et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Han, Claire J.
Reding, Kerryn W.
Kalady, Matthew F.
Yung, Rachel
Greenlee, Heather
Paskett, Electra D.
Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study)
title Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study)
title_full Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study)
title_fullStr Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study)
title_full_unstemmed Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study)
title_short Factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (WHI study)
title_sort factors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women’s health initiatives (whi study)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198480/
https://www.ncbi.nlm.nih.gov/pubmed/37205667
http://dx.doi.org/10.1371/journal.pone.0286058
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