Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8(+) T cell cytotoxicity and proliferation

Immune checkpoint inhibitors (ICIs) have caused revolutionary changes in cancer treatment, but low response rates remain a challenge. Semaphorin 4A (Sema4A) modulates the immune system through multiple mechanisms in mice, although the role of human Sema4A in the tumor microenvironment remains unclea...

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Detalles Bibliográficos
Autores principales: Naito, Yujiro, Koyama, Shohei, Masuhiro, Kentaro, Hirai, Takashi, Uenami, Takeshi, Inoue, Takako, Osa, Akio, Machiyama, Hirotomo, Watanabe, Go, Sax, Nicolas, Villa, Jordan, Kinugasa-Katayama, Yumi, Nojima, Satoshi, Yaga, Moto, Hosono, Yuki, Okuzaki, Daisuke, Satoh, Shingo, Tsuda, Takeshi, Nakanishi, Yoshimitsu, Suga, Yasuhiko, Morita, Takayoshi, Fukushima, Kiyoharu, Nishide, Masayuki, Shiroyama, Takayuki, Miyake, Kotaro, Iwahori, Kota, Hirata, Haruhiko, Nagatomo, Izumi, Yano, Yukihiro, Tamiya, Motohiro, Kumagai, Toru, Takemoto, Norihiko, Inohara, Hidenori, Yamasaki, Sho, Yamashita, Kazuo, Aoshi, Taiki, Akbay, Esra A., Hosen, Naoki, Shintani, Yasushi, Takamatsu, Hyota, Mori, Masahide, Takeda, Yoshito, Kumanogoh, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198637/
https://www.ncbi.nlm.nih.gov/pubmed/37205755
http://dx.doi.org/10.1126/sciadv.ade0718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198637/
https://www.ncbi.nlm.nih.gov/pubmed/37205755
http://dx.doi.org/10.1126/sciadv.ade0718

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