Evaluation of the clinical molecule anti-human-PD-L1/IL-15 KD033 in the human-PD-1/PD-L1-expressing murine model demonstrates PD-L1 targeting of IL-15 in vivo

KD033 is a clinical-stage immunocytokine composed of a high-affinity anti-human-PD-L1 antibody and the human IL-15/ IL-15 receptor sushi-domain complex. We have previously shown that KD033-surrogate, the anti-mouse-PD-L1/IL-15 immunocytokine, was efficacious in several syngeneic murine tumor models...

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Detalles Bibliográficos
Autores principales: Martomo, Stella A., Patel, Jeegar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198867/
https://www.ncbi.nlm.nih.gov/pubmed/36454338
http://dx.doi.org/10.1007/s00262-022-03331-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198867/
https://www.ncbi.nlm.nih.gov/pubmed/36454338
http://dx.doi.org/10.1007/s00262-022-03331-0

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