BAP1 and PTEN mutations shape the immunological landscape of clear cell renal cell carcinoma and reveal the intertumoral heterogeneity of T cell suppression: a proof-of-concept study

Clear cell renal cell carcinoma (ccRCC) is an immunologically vulnerable tumor entity, and immune checkpoint inhibitors are now widely used to treat patients with advanced disease. Whether and to what extent immune responses in ccRCC are shaped by genetic alterations, however, is only beginning to e...

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Detalles Bibliográficos
Autores principales: Friedhoff, Jana, Schneider, Felix, Jurcic, Christina, Endris, Volker, Kirchner, Martina, Sun, Angela, Bolnavu, Iulia, Pohl, Laura, Teroerde, Miriam, Kippenberger, Maximilian, Schwab, Constantin, Kaczorowski, Adam, Zschäbitz, Stefanie, Jäger, Dirk, Hohenfellner, Markus, Stenzinger, Albrecht, Duensing, Anette, Duensing, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198938/
https://www.ncbi.nlm.nih.gov/pubmed/36562826
http://dx.doi.org/10.1007/s00262-022-03346-7

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