ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases regulating PD-1 stability have been reported, deubiquitinases governing PD-1 homeostasis to modulate tumor immunotherapy remain u...

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Detalles Bibliográficos
Autores principales: Xiao, Xiangling, Shi, Jie, He, Chuan, Bu, Xia, Sun, Yishuang, Gao, Minling, Xiang, Bolin, Xiong, Wenjun, Dai, Panpan, Mao, Qi, Xing, Xixin, Yao, Yingmeng, Yu, Haisheng, Xu, Gaoshan, Li, Siqi, Ren, Yan, Chen, Baoxiang, Jiang, Congqing, Meng, Geng, Lee, Yu-Ru, Wei, Wenyi, Freeman, Gordon J., Xie, Conghua, Zhang, Jinfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199079/
https://www.ncbi.nlm.nih.gov/pubmed/37208329
http://dx.doi.org/10.1038/s41467-023-38605-3

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