Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine

Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman...

Descripción completa

Detalles Bibliográficos
Autores principales: de Malliard, Isabelle, Houist, Anne-Laure, Peytavin, Gilles, L’Yavanc, Thomas, Bouvier, Magali, Cappy, Pierre, Lelièvre, Jean-Daniel, Feredj, Elsa, Vindrios, William, Gallien, Sebastien, Melica, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199109/
https://www.ncbi.nlm.nih.gov/pubmed/37213429
http://dx.doi.org/10.1093/ofid/ofad217
Descripción
Sumario:Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m(2).

Ejemplares similares