Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine

Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman...

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Autores principales: de Malliard, Isabelle, Houist, Anne-Laure, Peytavin, Gilles, L’Yavanc, Thomas, Bouvier, Magali, Cappy, Pierre, Lelièvre, Jean-Daniel, Feredj, Elsa, Vindrios, William, Gallien, Sebastien, Melica, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199109/
https://www.ncbi.nlm.nih.gov/pubmed/37213429
http://dx.doi.org/10.1093/ofid/ofad217
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author de Malliard, Isabelle
Houist, Anne-Laure
Peytavin, Gilles
L’Yavanc, Thomas
Bouvier, Magali
Cappy, Pierre
Lelièvre, Jean-Daniel
Feredj, Elsa
Vindrios, William
Gallien, Sebastien
Melica, Giovanna
author_facet de Malliard, Isabelle
Houist, Anne-Laure
Peytavin, Gilles
L’Yavanc, Thomas
Bouvier, Magali
Cappy, Pierre
Lelièvre, Jean-Daniel
Feredj, Elsa
Vindrios, William
Gallien, Sebastien
Melica, Giovanna
author_sort de Malliard, Isabelle
collection PubMed
description Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m(2).
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spelling pubmed-101991092023-05-21 Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine de Malliard, Isabelle Houist, Anne-Laure Peytavin, Gilles L’Yavanc, Thomas Bouvier, Magali Cappy, Pierre Lelièvre, Jean-Daniel Feredj, Elsa Vindrios, William Gallien, Sebastien Melica, Giovanna Open Forum Infect Dis Brief Report Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m(2). Oxford University Press 2023-05-02 /pmc/articles/PMC10199109/ /pubmed/37213429 http://dx.doi.org/10.1093/ofid/ofad217 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
de Malliard, Isabelle
Houist, Anne-Laure
Peytavin, Gilles
L’Yavanc, Thomas
Bouvier, Magali
Cappy, Pierre
Lelièvre, Jean-Daniel
Feredj, Elsa
Vindrios, William
Gallien, Sebastien
Melica, Giovanna
Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine
title Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine
title_full Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine
title_fullStr Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine
title_full_unstemmed Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine
title_short Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine
title_sort gynoid fat distribution and adipocyte trapping may explain virological failure with intramuscular long-acting cabotegravir and rilpivirine
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199109/
https://www.ncbi.nlm.nih.gov/pubmed/37213429
http://dx.doi.org/10.1093/ofid/ofad217
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