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Reduced Cone Density Is Associated with Multiple Sclerosis
PURPOSE: Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system. Recent evidence suggests that degeneration of the inner layers of the retina occurs in MS. This study aimed to examine whether there are outer retinal changes in patients living with MS. DESI...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199246/ https://www.ncbi.nlm.nih.gov/pubmed/37214765 http://dx.doi.org/10.1016/j.xops.2023.100308 |
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author | McIlwaine, Gemma Csincsik, Lajos Coey, Rachel Wang, Luping Fitzgerald, Denise Moffat, Jill Dubis, Adam M. McDonnell, Gavin Hughes, Stella Peto, Tunde Lengyel, Imre |
author_facet | McIlwaine, Gemma Csincsik, Lajos Coey, Rachel Wang, Luping Fitzgerald, Denise Moffat, Jill Dubis, Adam M. McDonnell, Gavin Hughes, Stella Peto, Tunde Lengyel, Imre |
author_sort | McIlwaine, Gemma |
collection | PubMed |
description | PURPOSE: Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system. Recent evidence suggests that degeneration of the inner layers of the retina occurs in MS. This study aimed to examine whether there are outer retinal changes in patients living with MS. DESIGN: This was a single center, cross-sectional study. PARTICIPANTS: Sixteen patients with MS and 25 controls (volunteers without diagnosed MS) were recruited for the study. METHODS: We acquired volumetric spectral domain-OCT scans of the macula and a circular scan around the optic nerve head (ONH). We also captured adaptive optics (AO) images at 0° (centered on the foveola), 2°, 4°, and 6° temporal to the fovea. MAIN OUTCOME MEASURES: We calculated the thickness of the different retinal layers in the macula and around the ONH using the inbuilt software of the OCT. We evaluated changes in cone photoreceptors by calculating cone density and spacing by the inbuilt AO automatic segmentation algorithm with manual correction. We compared patients with and without optic neuritis and controls. RESULTS: We found significant thinning of the inner retina and a thickening of the outer retina in the eye with a history of optic neuritis (eyes of patients with MS with a history of optic neuritis; mean difference [MD]: −11.13 ± 3.61 μm, P = 0.002 and MD: 2.86 ± 0.89 μm, P = 0.001; respectively). We did not observe changes in retinal layers without optic neuritis in eyes of patients with MS without a history of optic neuritis. However, regional differences were detected in the peripapillary retinal nerve fiber layer. Analyzing AO images revealed a significantly lower cone outer-segment density at all eccentricities in all patients compared with control eyes (P < 0.05), independent of optic neuritis history. CONCLUSIONS: Our results showed that all MS cases were associated with decreased cone densities. Future longitudinal studies will help to elucidate whether this is a specific and sensitive method to detect and monitor the development and progression of MS. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references. |
format | Online Article Text |
id | pubmed-10199246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101992462023-05-21 Reduced Cone Density Is Associated with Multiple Sclerosis McIlwaine, Gemma Csincsik, Lajos Coey, Rachel Wang, Luping Fitzgerald, Denise Moffat, Jill Dubis, Adam M. McDonnell, Gavin Hughes, Stella Peto, Tunde Lengyel, Imre Ophthalmol Sci Original Article PURPOSE: Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system. Recent evidence suggests that degeneration of the inner layers of the retina occurs in MS. This study aimed to examine whether there are outer retinal changes in patients living with MS. DESIGN: This was a single center, cross-sectional study. PARTICIPANTS: Sixteen patients with MS and 25 controls (volunteers without diagnosed MS) were recruited for the study. METHODS: We acquired volumetric spectral domain-OCT scans of the macula and a circular scan around the optic nerve head (ONH). We also captured adaptive optics (AO) images at 0° (centered on the foveola), 2°, 4°, and 6° temporal to the fovea. MAIN OUTCOME MEASURES: We calculated the thickness of the different retinal layers in the macula and around the ONH using the inbuilt software of the OCT. We evaluated changes in cone photoreceptors by calculating cone density and spacing by the inbuilt AO automatic segmentation algorithm with manual correction. We compared patients with and without optic neuritis and controls. RESULTS: We found significant thinning of the inner retina and a thickening of the outer retina in the eye with a history of optic neuritis (eyes of patients with MS with a history of optic neuritis; mean difference [MD]: −11.13 ± 3.61 μm, P = 0.002 and MD: 2.86 ± 0.89 μm, P = 0.001; respectively). We did not observe changes in retinal layers without optic neuritis in eyes of patients with MS without a history of optic neuritis. However, regional differences were detected in the peripapillary retinal nerve fiber layer. Analyzing AO images revealed a significantly lower cone outer-segment density at all eccentricities in all patients compared with control eyes (P < 0.05), independent of optic neuritis history. CONCLUSIONS: Our results showed that all MS cases were associated with decreased cone densities. Future longitudinal studies will help to elucidate whether this is a specific and sensitive method to detect and monitor the development and progression of MS. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references. Elsevier 2023-04-13 /pmc/articles/PMC10199246/ /pubmed/37214765 http://dx.doi.org/10.1016/j.xops.2023.100308 Text en © 2023 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article McIlwaine, Gemma Csincsik, Lajos Coey, Rachel Wang, Luping Fitzgerald, Denise Moffat, Jill Dubis, Adam M. McDonnell, Gavin Hughes, Stella Peto, Tunde Lengyel, Imre Reduced Cone Density Is Associated with Multiple Sclerosis |
title | Reduced Cone Density Is Associated with Multiple Sclerosis |
title_full | Reduced Cone Density Is Associated with Multiple Sclerosis |
title_fullStr | Reduced Cone Density Is Associated with Multiple Sclerosis |
title_full_unstemmed | Reduced Cone Density Is Associated with Multiple Sclerosis |
title_short | Reduced Cone Density Is Associated with Multiple Sclerosis |
title_sort | reduced cone density is associated with multiple sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199246/ https://www.ncbi.nlm.nih.gov/pubmed/37214765 http://dx.doi.org/10.1016/j.xops.2023.100308 |
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