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Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry

BACKGROUND: While reporting of individual conflicts of interest is formalised, it is unclear to what extent the funding of clinical practice guidelines (CPGs) is formally reported. The aim of this study is to explore the accuracy and comprehensiveness of reporting on funding in German CPGs. METHODS:...

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Autores principales: Napierala, Hendrik, Schuster, Angela, Gehrke-Beck, Sabine, Heintze, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199475/
https://www.ncbi.nlm.nih.gov/pubmed/37208660
http://dx.doi.org/10.1186/s12910-023-00913-0
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author Napierala, Hendrik
Schuster, Angela
Gehrke-Beck, Sabine
Heintze, Christoph
author_facet Napierala, Hendrik
Schuster, Angela
Gehrke-Beck, Sabine
Heintze, Christoph
author_sort Napierala, Hendrik
collection PubMed
description BACKGROUND: While reporting of individual conflicts of interest is formalised, it is unclear to what extent the funding of clinical practice guidelines (CPGs) is formally reported. The aim of this study is to explore the accuracy and comprehensiveness of reporting on funding in German CPGs. METHODS: We searched for CPGs in the registry of the Association of the Scientific Medical Societies in Germany in July 2020. Information on guideline funding was categorised by two reviewers independently and discrepancies were clarified by discussion with a third reviewer. Accuracy and comprehensiveness of reporting on funding was assessed using the German Instrument for Methodological Guideline Appraisal (DELBI). RESULTS: We included 507 CPGs published between 2015 and 2020 in the main analysis. 23/507 (4.5%) of the CPGs achieved the highest DELBI score by including information on funding sources, expenses and the amount of funding provided, as well as a statement on the independence of the guideline authors from the funding institution(s). CPGs with more rigorous methodological requirements (systematic review of the literature and/or structured consensus-building) received higher DELBI scores. CONCLUSION: German CPGs do not communicate their funding transparently. Transparency of CPG funding could be achieved by making it mandatory to publish information for all guidelines. For that purpose, a standardised form and guidance should be developed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12910-023-00913-0.
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spelling pubmed-101994752023-05-21 Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry Napierala, Hendrik Schuster, Angela Gehrke-Beck, Sabine Heintze, Christoph BMC Med Ethics Research BACKGROUND: While reporting of individual conflicts of interest is formalised, it is unclear to what extent the funding of clinical practice guidelines (CPGs) is formally reported. The aim of this study is to explore the accuracy and comprehensiveness of reporting on funding in German CPGs. METHODS: We searched for CPGs in the registry of the Association of the Scientific Medical Societies in Germany in July 2020. Information on guideline funding was categorised by two reviewers independently and discrepancies were clarified by discussion with a third reviewer. Accuracy and comprehensiveness of reporting on funding was assessed using the German Instrument for Methodological Guideline Appraisal (DELBI). RESULTS: We included 507 CPGs published between 2015 and 2020 in the main analysis. 23/507 (4.5%) of the CPGs achieved the highest DELBI score by including information on funding sources, expenses and the amount of funding provided, as well as a statement on the independence of the guideline authors from the funding institution(s). CPGs with more rigorous methodological requirements (systematic review of the literature and/or structured consensus-building) received higher DELBI scores. CONCLUSION: German CPGs do not communicate their funding transparently. Transparency of CPG funding could be achieved by making it mandatory to publish information for all guidelines. For that purpose, a standardised form and guidance should be developed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12910-023-00913-0. BioMed Central 2023-05-19 /pmc/articles/PMC10199475/ /pubmed/37208660 http://dx.doi.org/10.1186/s12910-023-00913-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Napierala, Hendrik
Schuster, Angela
Gehrke-Beck, Sabine
Heintze, Christoph
Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry
title Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry
title_full Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry
title_fullStr Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry
title_full_unstemmed Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry
title_short Transparency of clinical practice guideline funding: a cross-sectional analysis of the German AWMF registry
title_sort transparency of clinical practice guideline funding: a cross-sectional analysis of the german awmf registry
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199475/
https://www.ncbi.nlm.nih.gov/pubmed/37208660
http://dx.doi.org/10.1186/s12910-023-00913-0
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