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Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study

PURPOSE: To evaluate the safety of spinal anesthesia in pregnant women who underwent cesarean section during the Covid-19 pandemia and were immunized with the BNT162b2 vaccine. METHODS: Historical cohort study that included three groups: non-vaccinated pregnant with no history of acute or previous C...

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Autores principales: Yamada, Eduardo J., Petró, Gabriel dS., Rohden, Guilherme B., Marques, Clandio T., Schwarzbold, Alexandre V., Backes, Dirce S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199485/
https://www.ncbi.nlm.nih.gov/pubmed/37260912
http://dx.doi.org/10.1016/j.pcorm.2023.100323
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author Yamada, Eduardo J.
Petró, Gabriel dS.
Rohden, Guilherme B.
Marques, Clandio T.
Schwarzbold, Alexandre V.
Backes, Dirce S.
author_facet Yamada, Eduardo J.
Petró, Gabriel dS.
Rohden, Guilherme B.
Marques, Clandio T.
Schwarzbold, Alexandre V.
Backes, Dirce S.
author_sort Yamada, Eduardo J.
collection PubMed
description PURPOSE: To evaluate the safety of spinal anesthesia in pregnant women who underwent cesarean section during the Covid-19 pandemia and were immunized with the BNT162b2 vaccine. METHODS: Historical cohort study that included three groups: non-vaccinated pregnant with no history of acute or previous Covid-19 [NV (n = 70)], vaccinated with one dose [1D (n = 65)] or two doses of BNT162b2 [2D (n = 45)], who underwent cesarean section with spinal anesthesia. Variables with normal distribution were analyzed with ANOVA. When one or more groups had non-normal distribution, the Kruskal-Wallis test was used. For categorical variables, the chi-square test or Kruskal-Wallis test was performed. When any variable had a frequency of less than five, the two-tailed Fisher's exact test with the Freeman-Halton extension was used. The significance level considered was p < .05. RESULTS: Apparently there is no interaction between BNT162b2 and the drugs most commonly used in spinal anesthesia for cesarean delivery. Conclusion: Performing spinal anesthesia in patients immunized with BNT162b2 does not seem to result in significant differences in outcomes compared to those not vaccinated. Apparently there is no need to change the standards of performing spinal anesthesia in patients vaccinated with the BNT162b2 vaccine.
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spelling pubmed-101994852023-05-22 Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study Yamada, Eduardo J. Petró, Gabriel dS. Rohden, Guilherme B. Marques, Clandio T. Schwarzbold, Alexandre V. Backes, Dirce S. Perioper Care Oper Room Manag Article PURPOSE: To evaluate the safety of spinal anesthesia in pregnant women who underwent cesarean section during the Covid-19 pandemia and were immunized with the BNT162b2 vaccine. METHODS: Historical cohort study that included three groups: non-vaccinated pregnant with no history of acute or previous Covid-19 [NV (n = 70)], vaccinated with one dose [1D (n = 65)] or two doses of BNT162b2 [2D (n = 45)], who underwent cesarean section with spinal anesthesia. Variables with normal distribution were analyzed with ANOVA. When one or more groups had non-normal distribution, the Kruskal-Wallis test was used. For categorical variables, the chi-square test or Kruskal-Wallis test was performed. When any variable had a frequency of less than five, the two-tailed Fisher's exact test with the Freeman-Halton extension was used. The significance level considered was p < .05. RESULTS: Apparently there is no interaction between BNT162b2 and the drugs most commonly used in spinal anesthesia for cesarean delivery. Conclusion: Performing spinal anesthesia in patients immunized with BNT162b2 does not seem to result in significant differences in outcomes compared to those not vaccinated. Apparently there is no need to change the standards of performing spinal anesthesia in patients vaccinated with the BNT162b2 vaccine. Elsevier Inc. 2023-09 2023-05-20 /pmc/articles/PMC10199485/ /pubmed/37260912 http://dx.doi.org/10.1016/j.pcorm.2023.100323 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yamada, Eduardo J.
Petró, Gabriel dS.
Rohden, Guilherme B.
Marques, Clandio T.
Schwarzbold, Alexandre V.
Backes, Dirce S.
Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study
title Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study
title_full Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study
title_fullStr Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study
title_full_unstemmed Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study
title_short Safety of spinal anesthesia in pregnant vaccinated with one or two doses of the BNT162b2 vaccine: A retrospective observational cohort study
title_sort safety of spinal anesthesia in pregnant vaccinated with one or two doses of the bnt162b2 vaccine: a retrospective observational cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199485/
https://www.ncbi.nlm.nih.gov/pubmed/37260912
http://dx.doi.org/10.1016/j.pcorm.2023.100323
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