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The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer

BACKGROUND: The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yield novel molecular targets or mechanisms amenable to inhibition strategies. Phospholipids availability has been appreciated as a mechanism to modulate KRAS oncogenic...

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Detalles Bibliográficos
Autores principales:	Entrialgo-Cadierno, Rodrigo, Cueto-Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi-Salaverri, Ainhoa, Lara-Astiaso, David, Halberg, Nils, Cortes-Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando, Vicent, Silve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199551/ https://www.ncbi.nlm.nih.gov/pubmed/37210549 http://dx.doi.org/10.1186/s12943-023-01788-w

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