Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different...

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Autores principales: El-Husseiny Moustafa, Fatma, Nagy, Eman, Elwasif, Salwa Mahmoud, Sobh, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199555/
https://www.ncbi.nlm.nih.gov/pubmed/37208636
http://dx.doi.org/10.1186/s12882-023-03185-3
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author El-Husseiny Moustafa, Fatma
Nagy, Eman
Elwasif, Salwa Mahmoud
Sobh, Mohamed
author_facet El-Husseiny Moustafa, Fatma
Nagy, Eman
Elwasif, Salwa Mahmoud
Sobh, Mohamed
author_sort El-Husseiny Moustafa, Fatma
collection PubMed
description Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.
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spelling pubmed-101995552023-05-21 Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature El-Husseiny Moustafa, Fatma Nagy, Eman Elwasif, Salwa Mahmoud Sobh, Mohamed BMC Nephrol Case Report Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well. BioMed Central 2023-05-19 /pmc/articles/PMC10199555/ /pubmed/37208636 http://dx.doi.org/10.1186/s12882-023-03185-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
El-Husseiny Moustafa, Fatma
Nagy, Eman
Elwasif, Salwa Mahmoud
Sobh, Mohamed
Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
title Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
title_full Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
title_fullStr Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
title_full_unstemmed Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
title_short Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
title_sort karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199555/
https://www.ncbi.nlm.nih.gov/pubmed/37208636
http://dx.doi.org/10.1186/s12882-023-03185-3
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