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Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis
BACKGROUND: To develop and assess the performance of machine learning (ML) models based on magnetic resonance imaging (MRI) radiomics analysis for knee osteoarthritis (KOA) diagnosis. METHODS: This retrospective study analysed 148 consecutive patients (72 with KOA and 76 without) with available MRI...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199595/ https://www.ncbi.nlm.nih.gov/pubmed/37210510 http://dx.doi.org/10.1186/s13018-023-03837-y |
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author | Cui, Tingrun Liu, Ruilong Jing, Yang Fu, Jun Chen, Jiying |
author_facet | Cui, Tingrun Liu, Ruilong Jing, Yang Fu, Jun Chen, Jiying |
author_sort | Cui, Tingrun |
collection | PubMed |
description | BACKGROUND: To develop and assess the performance of machine learning (ML) models based on magnetic resonance imaging (MRI) radiomics analysis for knee osteoarthritis (KOA) diagnosis. METHODS: This retrospective study analysed 148 consecutive patients (72 with KOA and 76 without) with available MRI image data, where radiomics features in cartilage portions were extracted and then filtered. Intraclass correlation coefficient (ICC) was calculated to quantify the reproducibility of features, and a threshold of 0.8 was set. The training and validation cohorts consisted of 117 and 31 cases, respectively. Least absolute shrinkage and selection operator (LASSO) regression method was employed for feature selection. The ML classifiers were logistic regression (LR), K-nearest neighbour (KNN) and support vector machine (SVM). In each algorithm, ten models derived from all available planes of three joint compartments and their various combinations were, respectively, constructed for comparative analysis. The performance of classifiers was mainly evaluated and compared by receiver operating characteristic (ROC) analysis. RESULTS: All models achieved satisfying performances, especially the Final model, where accuracy and area under ROC curve (AUC) of LR classifier were 0.968, 0.983 (0.957–1.000, 95% CI) in the validation cohort, and 0.940, 0.984 (0.969–0.995, 95% CI) in the training cohort, respectively. CONCLUSION: The MRI radiomics analysis represented promising performance in noninvasive and preoperative KOA diagnosis, especially when considering all available planes of all three compartments of knee joints. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13018-023-03837-y. |
format | Online Article Text |
id | pubmed-10199595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101995952023-05-21 Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis Cui, Tingrun Liu, Ruilong Jing, Yang Fu, Jun Chen, Jiying J Orthop Surg Res Research Article BACKGROUND: To develop and assess the performance of machine learning (ML) models based on magnetic resonance imaging (MRI) radiomics analysis for knee osteoarthritis (KOA) diagnosis. METHODS: This retrospective study analysed 148 consecutive patients (72 with KOA and 76 without) with available MRI image data, where radiomics features in cartilage portions were extracted and then filtered. Intraclass correlation coefficient (ICC) was calculated to quantify the reproducibility of features, and a threshold of 0.8 was set. The training and validation cohorts consisted of 117 and 31 cases, respectively. Least absolute shrinkage and selection operator (LASSO) regression method was employed for feature selection. The ML classifiers were logistic regression (LR), K-nearest neighbour (KNN) and support vector machine (SVM). In each algorithm, ten models derived from all available planes of three joint compartments and their various combinations were, respectively, constructed for comparative analysis. The performance of classifiers was mainly evaluated and compared by receiver operating characteristic (ROC) analysis. RESULTS: All models achieved satisfying performances, especially the Final model, where accuracy and area under ROC curve (AUC) of LR classifier were 0.968, 0.983 (0.957–1.000, 95% CI) in the validation cohort, and 0.940, 0.984 (0.969–0.995, 95% CI) in the training cohort, respectively. CONCLUSION: The MRI radiomics analysis represented promising performance in noninvasive and preoperative KOA diagnosis, especially when considering all available planes of all three compartments of knee joints. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13018-023-03837-y. BioMed Central 2023-05-20 /pmc/articles/PMC10199595/ /pubmed/37210510 http://dx.doi.org/10.1186/s13018-023-03837-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Cui, Tingrun Liu, Ruilong Jing, Yang Fu, Jun Chen, Jiying Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis |
title | Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis |
title_full | Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis |
title_fullStr | Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis |
title_full_unstemmed | Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis |
title_short | Development of machine learning models aiming at knee osteoarthritis diagnosing: an MRI radiomics analysis |
title_sort | development of machine learning models aiming at knee osteoarthritis diagnosing: an mri radiomics analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199595/ https://www.ncbi.nlm.nih.gov/pubmed/37210510 http://dx.doi.org/10.1186/s13018-023-03837-y |
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