Cargando…

Nicotinamide ameliorates mitochondria-related neuronal apoptosis and cognitive impairment via the NAD(+)/SIRT3 pathway

Emerging evidence suggests that mitochondria play a central role in mental health disorders including schizophrenia. Here we investigated whether nicotinamide (NAM) normalized cognitive impairment via a mechanism involving the mitochondrial Sirtuin 3 (SIRT3) pathway. The 24 h maternal separation (MS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hao, Keke, Chen, Fashuai, Zhao, Linyao, Xu, Shilin, Xiong, Ying, Xu, Rui, Xie, Xinhui, Huang, Huan, Shu, Chang, Liu, Zhongchun, Wang, Huiling, Wang, Gaohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199898/ https://www.ncbi.nlm.nih.gov/pubmed/37210391 http://dx.doi.org/10.1038/s41537-023-00357-w

Ejemplares similares

Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation
por: Hao, Keke, et al.
Publicado: (2022)

Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress
por: Xu, Shilin, et al.
Publicado: (2023)

Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD(+)–Sirt1 signaling
por: Pi, Chenchen, et al.
Publicado: (2019)

Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD(+)/Sirt3 Pathway in Mesenchymal Stem Cells
por: Wang, Huan, et al.
Publicado: (2022)

Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD(+)/SIRT1 axis
por: Wu, Keke, et al.
Publicado: (2023)

Polyphosphate-dependent nicotinamide adenine dinucleotide (NAD) kinase: A novel missing link in human mitochondria
por: MURATA, Kousaku
Publicado: (2021)

β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice
por: Li, Hui-ru, et al.
Publicado: (2023)

The emergence of the nicotinamide riboside kinases in the regulation of NAD(+) metabolism
por: Fletcher, Rachel S, et al.
Publicado: (2018)

Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice
por: Liu, Zhuxi, et al.
Publicado: (2020)

NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health
por: Alegre, Gabriela Fabiana Soares, et al.
Publicado: (2023)

The Effect of Nicotinamide Riboside, an NAD + Precursor, on Glycolysis and NAD + Salvage Pathway in Alcohol-Stimulated Macrophages
por: Kang, Hyunju, et al.
Publicado: (2022)

Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD)
por: Yaku, Keisuke, et al.
Publicado: (2019)

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway
por: Feng, Duo, et al.
Publicado: (2020)

Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+)
por: Tempel, Wolfram, et al.
Publicado: (2007)

The NAD(+) precursor nicotinamide riboside decreases exercise performance in rats
por: Kourtzidis, Ioannis A., et al.
Publicado: (2016)

Balancing NAD(+) deficits with nicotinamide riboside: therapeutic possibilities and limitations
por: Cercillieux, Angelique, et al.
Publicado: (2022)

Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2
por: Hasegawa, Kazuhiro, et al.
Publicado: (2022)

Impaired nicotinamide adenine dinucleotide (NAD(+)) metabolism in diabetes and diabetic tissues: Implications for nicotinamide‐related compound treatment
por: Fan, Lan, et al.
Publicado: (2020)

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD(+)-Sirt1 pathway
por: Pi, Chenchen, et al.
Publicado: (2021)

The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease
por: Takahashi, Rina, et al.
Publicado: (2022)

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD
por: Sverkeli, Lars Jansen, et al.
Publicado: (2021)

Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer
por: Navas, Lola E., et al.
Publicado: (2022)

Nicotinamide restores tissue NAD(+) and improves survival in rodent models of cardiac arrest
por: Zhu, Xiangdong, et al.
Publicado: (2023)

SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure
por: Buonvicino, Daniela, et al.
Publicado: (2021)

Nicotinamide-mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis
por: WANG, TONG, et al.
Publicado: (2013)

Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia
por: Huang, Huan, et al.
Publicado: (2023)

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria
por: Davila, Antonio, et al.
Publicado: (2018)

Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
por: Rymarchyk, Stacia, et al.
Publicado: (2021)

Nicotinamide Mononucleotide, an Intermediate of NAD(+) Synthesis, Protects the Heart from Ischemia and Reperfusion
por: Yamamoto, Takanobu, et al.
Publicado: (2014)

Potential of nicotinamide adenine dinucleotide (NAD) for management of root-knot nematode in tomato
por: Regmi, Homan, et al.
Publicado: (2021)

Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms
por: Torres-Méndez, Jeimy Katherine, et al.
Publicado: (2023)

Prefrontal Cortex Activation During Verbal Fluency Task and Tower of London Task in Schizophrenia and Major Depressive Disorder
por: Xiang, Yilei, et al.
Publicado: (2021)

Nicotinamide Phosphoribosyltransferase‐elevated NAD(+) biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction
por: Zhang, Yao, et al.
Publicado: (2023)

Sirt1 and the Mitochondria
por: Tang, Bor Luen
Publicado: (2016)

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor
por: Giroud-Gerbetant, Judith, et al.
Publicado: (2019)

The Role of NAD+, SIRTs Interactions in Stimulating and Counteracting Carcinogenesis
por: Podyacheva, Ekaterina, et al.
Publicado: (2023)

β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
por: Lu, Christopher Y.
Publicado: (2014)

Anxiety and Depression in Patients With Physical Diseases and Associated Factors: A Large-Scale Field Survey in General Hospitals in China
por: Yang, Wanlin, et al.
Publicado: (2021)

Resting-state functional connectivity of salience network in schizophrenia and depression
por: Huang, Huan, et al.
Publicado: (2022)

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism
por: Hong, Weiqi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8j72fkvugqv20nko8cjsikhqd0