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Effects of working memory load and CS-US intervals on delay eyeblink conditioning

Eyeblink conditioning is used in many species to study motor learning and make inferences about cerebellar function. However, the discrepancies in performance between humans and other species combined with evidence that volition and awareness can modulate learning suggest that eyeblink conditioning...

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Autores principales: Etemadi, Leila, Jirenhed, Dan-Anders, Rasmussen, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199915/
https://www.ncbi.nlm.nih.gov/pubmed/37210441
http://dx.doi.org/10.1038/s41539-023-00167-w
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author Etemadi, Leila
Jirenhed, Dan-Anders
Rasmussen, Anders
author_facet Etemadi, Leila
Jirenhed, Dan-Anders
Rasmussen, Anders
author_sort Etemadi, Leila
collection PubMed
description Eyeblink conditioning is used in many species to study motor learning and make inferences about cerebellar function. However, the discrepancies in performance between humans and other species combined with evidence that volition and awareness can modulate learning suggest that eyeblink conditioning is not merely a passive form of learning that relies on only the cerebellum. Here we explored two ways to reduce the influence of volition and awareness on eyeblink conditioning: (1) using a short interstimulus interval, and (2) having participants do working memory tasks during the conditioning. Our results show that participants trained with short interstimulus intervals (150 ms and 250 ms) produce very few conditioned responses after 100 trials. Participants trained with a longer interstimulus interval (500 ms) who simultaneously did working memory tasks produced fewer conditioned responses than participants who watched a movie during the training. Our results suggest that having participants perform working memory tasks during eyeblink conditioning can be a viable strategy for studying cerebellar learning that is absent of influences from awareness and volition. This could enhance the comparability of the results obtained in human studies with those in animal models.
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spelling pubmed-101999152023-05-22 Effects of working memory load and CS-US intervals on delay eyeblink conditioning Etemadi, Leila Jirenhed, Dan-Anders Rasmussen, Anders NPJ Sci Learn Article Eyeblink conditioning is used in many species to study motor learning and make inferences about cerebellar function. However, the discrepancies in performance between humans and other species combined with evidence that volition and awareness can modulate learning suggest that eyeblink conditioning is not merely a passive form of learning that relies on only the cerebellum. Here we explored two ways to reduce the influence of volition and awareness on eyeblink conditioning: (1) using a short interstimulus interval, and (2) having participants do working memory tasks during the conditioning. Our results show that participants trained with short interstimulus intervals (150 ms and 250 ms) produce very few conditioned responses after 100 trials. Participants trained with a longer interstimulus interval (500 ms) who simultaneously did working memory tasks produced fewer conditioned responses than participants who watched a movie during the training. Our results suggest that having participants perform working memory tasks during eyeblink conditioning can be a viable strategy for studying cerebellar learning that is absent of influences from awareness and volition. This could enhance the comparability of the results obtained in human studies with those in animal models. Nature Publishing Group UK 2023-05-20 /pmc/articles/PMC10199915/ /pubmed/37210441 http://dx.doi.org/10.1038/s41539-023-00167-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Etemadi, Leila
Jirenhed, Dan-Anders
Rasmussen, Anders
Effects of working memory load and CS-US intervals on delay eyeblink conditioning
title Effects of working memory load and CS-US intervals on delay eyeblink conditioning
title_full Effects of working memory load and CS-US intervals on delay eyeblink conditioning
title_fullStr Effects of working memory load and CS-US intervals on delay eyeblink conditioning
title_full_unstemmed Effects of working memory load and CS-US intervals on delay eyeblink conditioning
title_short Effects of working memory load and CS-US intervals on delay eyeblink conditioning
title_sort effects of working memory load and cs-us intervals on delay eyeblink conditioning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199915/
https://www.ncbi.nlm.nih.gov/pubmed/37210441
http://dx.doi.org/10.1038/s41539-023-00167-w
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