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Reproduction of bacterial chemotaxis by a non-living self-propelled object
Taxic behavior as a response to an external stimulus is a fundamental function of living organisms. Some bacteria successfully implement chemotaxis without directly controlling the direction of movement. They periodically alternate between run and tumble, i.e., straight movement and change in direct...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199926/ https://www.ncbi.nlm.nih.gov/pubmed/37210558 http://dx.doi.org/10.1038/s41598-023-34788-3 |
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author | Hamano, Yuko Ikeda, Kota Odagiri, Kenta Suematsu, Nobuhiko J. |
author_facet | Hamano, Yuko Ikeda, Kota Odagiri, Kenta Suematsu, Nobuhiko J. |
author_sort | Hamano, Yuko |
collection | PubMed |
description | Taxic behavior as a response to an external stimulus is a fundamental function of living organisms. Some bacteria successfully implement chemotaxis without directly controlling the direction of movement. They periodically alternate between run and tumble, i.e., straight movement and change in direction, respectively. They tune their running period depending on the concentration gradient of attractants around them. Consequently, they respond to a gentle concentration gradient stochastically, which is called “bacterial chemotaxis.” In this study, such a stochastic response was reproduced by a non-living self-propelled object. We used a phenanthroline disk floating on an aqueous solution of Fe[Formula: see text] . The disk spontaneously alternated between rapid motion and rest, similar to the run-and-tumble motion of bacteria. The movement direction of the disk was isotropic independent of the concentration gradient. However, the existing probability of the self-propelled object was higher at the low-concentration region, where the run length was longer. To explain the mechanism underlying this phenomenon, we proposed a simple mathematical model that considers random walkers whose run length depends on the local concentration and direction of movement against the gradient. Our model adopts deterministic functions to reproduce the both effects, which is instead of stochastic tuning the period of operation used in the previous reports. This allows us to analyze the proposed model mathematically, which indicated that our model reproduces both positive and negative chemotaxis depending on the competition between the local concentration effect and it’s gradient effect. Owing to the newly introduced directional bias, the experimental observations were reproduced numerically and analytically. The results indicate that the directional bias response to the concentration gradient is an essential parameter for determining bacterial chemotaxis. This rule might be universal for the stochastic response of self-propelled particles in living and non-living systems. |
format | Online Article Text |
id | pubmed-10199926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101999262023-05-22 Reproduction of bacterial chemotaxis by a non-living self-propelled object Hamano, Yuko Ikeda, Kota Odagiri, Kenta Suematsu, Nobuhiko J. Sci Rep Article Taxic behavior as a response to an external stimulus is a fundamental function of living organisms. Some bacteria successfully implement chemotaxis without directly controlling the direction of movement. They periodically alternate between run and tumble, i.e., straight movement and change in direction, respectively. They tune their running period depending on the concentration gradient of attractants around them. Consequently, they respond to a gentle concentration gradient stochastically, which is called “bacterial chemotaxis.” In this study, such a stochastic response was reproduced by a non-living self-propelled object. We used a phenanthroline disk floating on an aqueous solution of Fe[Formula: see text] . The disk spontaneously alternated between rapid motion and rest, similar to the run-and-tumble motion of bacteria. The movement direction of the disk was isotropic independent of the concentration gradient. However, the existing probability of the self-propelled object was higher at the low-concentration region, where the run length was longer. To explain the mechanism underlying this phenomenon, we proposed a simple mathematical model that considers random walkers whose run length depends on the local concentration and direction of movement against the gradient. Our model adopts deterministic functions to reproduce the both effects, which is instead of stochastic tuning the period of operation used in the previous reports. This allows us to analyze the proposed model mathematically, which indicated that our model reproduces both positive and negative chemotaxis depending on the competition between the local concentration effect and it’s gradient effect. Owing to the newly introduced directional bias, the experimental observations were reproduced numerically and analytically. The results indicate that the directional bias response to the concentration gradient is an essential parameter for determining bacterial chemotaxis. This rule might be universal for the stochastic response of self-propelled particles in living and non-living systems. Nature Publishing Group UK 2023-05-20 /pmc/articles/PMC10199926/ /pubmed/37210558 http://dx.doi.org/10.1038/s41598-023-34788-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hamano, Yuko Ikeda, Kota Odagiri, Kenta Suematsu, Nobuhiko J. Reproduction of bacterial chemotaxis by a non-living self-propelled object |
title | Reproduction of bacterial chemotaxis by a non-living self-propelled object |
title_full | Reproduction of bacterial chemotaxis by a non-living self-propelled object |
title_fullStr | Reproduction of bacterial chemotaxis by a non-living self-propelled object |
title_full_unstemmed | Reproduction of bacterial chemotaxis by a non-living self-propelled object |
title_short | Reproduction of bacterial chemotaxis by a non-living self-propelled object |
title_sort | reproduction of bacterial chemotaxis by a non-living self-propelled object |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199926/ https://www.ncbi.nlm.nih.gov/pubmed/37210558 http://dx.doi.org/10.1038/s41598-023-34788-3 |
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