Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) has relatively ineffective first/second-line therapy for advanced disease and only 18% five-year survival for early disease. Drug-induced mitochondrial priming measured by dynamic BH3 profiling identifies efficacious drugs in multiple disease settings. We use hig...

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Detalles Bibliográficos
Autores principales: Potter, Danielle S., Du, Ruochen, Bohl, Stephan R., Chow, Kin-Hoe, Ligon, Keith L., Bueno, Raphael, Letai, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199949/
https://www.ncbi.nlm.nih.gov/pubmed/37210412
http://dx.doi.org/10.1038/s41467-023-38552-z

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