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A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes

Aim and objectives The infection of microbial agents in cirrhosis has increased due to poor immunity, which increases morbidities and mortalities worldwide. The present study aimed to assess the incidence, the type of infections, the pattern of resistance, and the course of hospitalization among cir...

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Autores principales: Patnaik, Swarup K, Mohanty, Sambedana, Mishra, Debakanta, Kanungo, Manjit, Patil, Srinith, Teja, Ram Gopal, Uthansingh, Kanishka, Narayan, Jimmy, Sahu, Manoj K, Pati, Girish K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200015/
https://www.ncbi.nlm.nih.gov/pubmed/37220470
http://dx.doi.org/10.7759/cureus.37912
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author Patnaik, Swarup K
Mohanty, Sambedana
Mishra, Debakanta
Kanungo, Manjit
Patil, Srinith
Teja, Ram Gopal
Uthansingh, Kanishka
Narayan, Jimmy
Sahu, Manoj K
Pati, Girish K
author_facet Patnaik, Swarup K
Mohanty, Sambedana
Mishra, Debakanta
Kanungo, Manjit
Patil, Srinith
Teja, Ram Gopal
Uthansingh, Kanishka
Narayan, Jimmy
Sahu, Manoj K
Pati, Girish K
author_sort Patnaik, Swarup K
collection PubMed
description Aim and objectives The infection of microbial agents in cirrhosis has increased due to poor immunity, which increases morbidities and mortalities worldwide. The present study aimed to assess the incidence, the type of infections, the pattern of resistance, and the course of hospitalization among cirrhotic patients in the Eastern coastal region. Methodology The study was a descriptive cross-sectional study, and the current study was undertaken for 24 months at the Department of Gastroenterology and Hepatobiliary Sciences, IMS, and SUM. Hospital, Bhubaneswar. Consecutive cirrhotic patients admitted with bacterial infection were prospectively evaluated, and the infection patterns were accessed. The data were collected in a well-structured proforma designed by our study team. Results Out of the total 200 cases, a fraction of 72.5% of males outnumbered the females; the mean age of presentation was 59 ± 12 years. A fraction of 59% of cases had the habit of consuming alcohol which amounted to the predominant etiological factor for cirrhosis, followed by non-alcoholic steatohepatitis (NASH). Urinary tract infection (UTI) and spontaneous bacterial peritonitis (SBP) were more common types of infections in the healthcare-associated (HCA) group; however, pneumonia and skin and soft tissue infections (SSTI) were predominant types of infections in community-acquired (CA) group. The model for end-stage liver disease (MELD) scores were not significantly different amongst the three groups with infections at the time of Diagnosis infection and at the time of hospitalization. However, the MELD scores were substantially higher at the time of infection diagnosis than the MELD scores at the time of admission amongst the three groups with infection. Conclusion The present study showed that infections in cirrhosis were relatively common. Due to increasing resistance patterns, the judicious usage of antibiotics in cirrhosis could be the need of the hour.
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spelling pubmed-102000152023-05-22 A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes Patnaik, Swarup K Mohanty, Sambedana Mishra, Debakanta Kanungo, Manjit Patil, Srinith Teja, Ram Gopal Uthansingh, Kanishka Narayan, Jimmy Sahu, Manoj K Pati, Girish K Cureus Gastroenterology Aim and objectives The infection of microbial agents in cirrhosis has increased due to poor immunity, which increases morbidities and mortalities worldwide. The present study aimed to assess the incidence, the type of infections, the pattern of resistance, and the course of hospitalization among cirrhotic patients in the Eastern coastal region. Methodology The study was a descriptive cross-sectional study, and the current study was undertaken for 24 months at the Department of Gastroenterology and Hepatobiliary Sciences, IMS, and SUM. Hospital, Bhubaneswar. Consecutive cirrhotic patients admitted with bacterial infection were prospectively evaluated, and the infection patterns were accessed. The data were collected in a well-structured proforma designed by our study team. Results Out of the total 200 cases, a fraction of 72.5% of males outnumbered the females; the mean age of presentation was 59 ± 12 years. A fraction of 59% of cases had the habit of consuming alcohol which amounted to the predominant etiological factor for cirrhosis, followed by non-alcoholic steatohepatitis (NASH). Urinary tract infection (UTI) and spontaneous bacterial peritonitis (SBP) were more common types of infections in the healthcare-associated (HCA) group; however, pneumonia and skin and soft tissue infections (SSTI) were predominant types of infections in community-acquired (CA) group. The model for end-stage liver disease (MELD) scores were not significantly different amongst the three groups with infections at the time of Diagnosis infection and at the time of hospitalization. However, the MELD scores were substantially higher at the time of infection diagnosis than the MELD scores at the time of admission amongst the three groups with infection. Conclusion The present study showed that infections in cirrhosis were relatively common. Due to increasing resistance patterns, the judicious usage of antibiotics in cirrhosis could be the need of the hour. Cureus 2023-04-21 /pmc/articles/PMC10200015/ /pubmed/37220470 http://dx.doi.org/10.7759/cureus.37912 Text en Copyright © 2023, Patnaik et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Patnaik, Swarup K
Mohanty, Sambedana
Mishra, Debakanta
Kanungo, Manjit
Patil, Srinith
Teja, Ram Gopal
Uthansingh, Kanishka
Narayan, Jimmy
Sahu, Manoj K
Pati, Girish K
A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes
title A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes
title_full A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes
title_fullStr A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes
title_full_unstemmed A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes
title_short A Prospective Study on the Clinical Significance of Infections in a Hospital Setting Among the Cirrhotic Patients and Their Outcomes
title_sort prospective study on the clinical significance of infections in a hospital setting among the cirrhotic patients and their outcomes
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200015/
https://www.ncbi.nlm.nih.gov/pubmed/37220470
http://dx.doi.org/10.7759/cureus.37912
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