Cargando…

Sparcl1 and Atherosclerosis

Atherosclerosis and its complications constitute some of the major diseases affecting humans worldwide. A core component of atherogenesis is endothelial cell damage and dysfunction, which also includes factors such as adhesion and proliferation of various cells. Multiple studies have shown that athe...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Xu, Chen, Xinyan, Zhang, Min, Wan, Yufeng, Ge, Shenglin, Cheng, Xiaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200116/
https://www.ncbi.nlm.nih.gov/pubmed/37220502
http://dx.doi.org/10.2147/JIR.S406907
_version_ 1785045070760640512
author Cheng, Xu
Chen, Xinyan
Zhang, Min
Wan, Yufeng
Ge, Shenglin
Cheng, Xiaowen
author_facet Cheng, Xu
Chen, Xinyan
Zhang, Min
Wan, Yufeng
Ge, Shenglin
Cheng, Xiaowen
author_sort Cheng, Xu
collection PubMed
description Atherosclerosis and its complications constitute some of the major diseases affecting humans worldwide. A core component of atherogenesis is endothelial cell damage and dysfunction, which also includes factors such as adhesion and proliferation of various cells. Multiple studies have shown that atherosclerosis and cancer share a common pathophysiological process and exhibit a degree of similarity. Sparcl-1 is a cysteine-rich secretory stromal cell protein present in the extracellular matrix and belongs to the Sparc family of proteins. Its role in tumor development has been widely investigated; however, its role in cardiovascular diseases has rarely been studied. Sparcl-1 is considered an oncogene correlated with the regulation of cell adhesion, migration, and proliferation and is also related to blood vessel integrity. In this review, the potential link between Sparcl-1 and atherosclerosis development is investigated, and recommendations on future research on the role of Sparcl-1 in atherogenesis are provided.
format Online
Article
Text
id pubmed-10200116
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-102001162023-05-22 Sparcl1 and Atherosclerosis Cheng, Xu Chen, Xinyan Zhang, Min Wan, Yufeng Ge, Shenglin Cheng, Xiaowen J Inflamm Res Review Atherosclerosis and its complications constitute some of the major diseases affecting humans worldwide. A core component of atherogenesis is endothelial cell damage and dysfunction, which also includes factors such as adhesion and proliferation of various cells. Multiple studies have shown that atherosclerosis and cancer share a common pathophysiological process and exhibit a degree of similarity. Sparcl-1 is a cysteine-rich secretory stromal cell protein present in the extracellular matrix and belongs to the Sparc family of proteins. Its role in tumor development has been widely investigated; however, its role in cardiovascular diseases has rarely been studied. Sparcl-1 is considered an oncogene correlated with the regulation of cell adhesion, migration, and proliferation and is also related to blood vessel integrity. In this review, the potential link between Sparcl-1 and atherosclerosis development is investigated, and recommendations on future research on the role of Sparcl-1 in atherogenesis are provided. Dove 2023-05-17 /pmc/articles/PMC10200116/ /pubmed/37220502 http://dx.doi.org/10.2147/JIR.S406907 Text en © 2023 Cheng et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Cheng, Xu
Chen, Xinyan
Zhang, Min
Wan, Yufeng
Ge, Shenglin
Cheng, Xiaowen
Sparcl1 and Atherosclerosis
title Sparcl1 and Atherosclerosis
title_full Sparcl1 and Atherosclerosis
title_fullStr Sparcl1 and Atherosclerosis
title_full_unstemmed Sparcl1 and Atherosclerosis
title_short Sparcl1 and Atherosclerosis
title_sort sparcl1 and atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200116/
https://www.ncbi.nlm.nih.gov/pubmed/37220502
http://dx.doi.org/10.2147/JIR.S406907
work_keys_str_mv AT chengxu sparcl1andatherosclerosis
AT chenxinyan sparcl1andatherosclerosis
AT zhangmin sparcl1andatherosclerosis
AT wanyufeng sparcl1andatherosclerosis
AT geshenglin sparcl1andatherosclerosis
AT chengxiaowen sparcl1andatherosclerosis