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Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start

Three decades with the amyloid hypothesis, nearly two with amyloid-PET imaging, and one with testing of anti-amyloid therapy have not yielded benefits to patients with Alzheimer’s disease (AD). It is time to focus on more promising options, e.g., infection, low dose radiation, and atherosclerosis. T...

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Autores principales: Høilund-Carlsen, Poul F., Revheim, Mona-Elisabeth, Alavi, Abass
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200191/
https://www.ncbi.nlm.nih.gov/pubmed/35599491
http://dx.doi.org/10.3233/JAD-220190
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author Høilund-Carlsen, Poul F.
Revheim, Mona-Elisabeth
Alavi, Abass
author_facet Høilund-Carlsen, Poul F.
Revheim, Mona-Elisabeth
Alavi, Abass
author_sort Høilund-Carlsen, Poul F.
collection PubMed
description Three decades with the amyloid hypothesis, nearly two with amyloid-PET imaging, and one with testing of anti-amyloid therapy have not yielded benefits to patients with Alzheimer’s disease (AD). It is time to focus on more promising options, e.g., infection, low dose radiation, and atherosclerosis. The relevance of the latter in managing AD has fluctuated from being significant to insignificant. Current methodologies for detecting cerebral atherosclerosis reflect advanced changes in only major arteries. In contrast, (18)F-sodium fluoride PET imaging assessing early-stage cerebral atherosclerosis regionally or in the entire vascular bed may provide new insight in this age-related process in dementia.
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spelling pubmed-102001912023-05-22 Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start Høilund-Carlsen, Poul F. Revheim, Mona-Elisabeth Alavi, Abass J Alzheimers Dis Commentary Three decades with the amyloid hypothesis, nearly two with amyloid-PET imaging, and one with testing of anti-amyloid therapy have not yielded benefits to patients with Alzheimer’s disease (AD). It is time to focus on more promising options, e.g., infection, low dose radiation, and atherosclerosis. The relevance of the latter in managing AD has fluctuated from being significant to insignificant. Current methodologies for detecting cerebral atherosclerosis reflect advanced changes in only major arteries. In contrast, (18)F-sodium fluoride PET imaging assessing early-stage cerebral atherosclerosis regionally or in the entire vascular bed may provide new insight in this age-related process in dementia. IOS Press 2022-07-19 /pmc/articles/PMC10200191/ /pubmed/35599491 http://dx.doi.org/10.3233/JAD-220190 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Høilund-Carlsen, Poul F.
Revheim, Mona-Elisabeth
Alavi, Abass
Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start
title Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start
title_full Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start
title_fullStr Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start
title_full_unstemmed Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start
title_short Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start
title_sort alzheimer’s disease at a crossroad: time to part from amyloid to more promising aspects—atherosclerosis for a start
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200191/
https://www.ncbi.nlm.nih.gov/pubmed/35599491
http://dx.doi.org/10.3233/JAD-220190
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