Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease

Major depressive disorder (MDD) is a risk factor for Alzheimer’s disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD...

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Detalles Bibliográficos
Autores principales: Golas, Angela C., Salwierz, Patrick, Rajji, Tarek K., Bowie, Christopher R., Butters, Meryl A., Fischer, Corinne E., Flint, Alastair J., Herrmann, Nathan, Mah, Linda, Mulsant, Benoit H., Pollock, Bruce G., Taghdiri, Foad, Wang, Wei, Tartaglia, M. Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200207/
https://www.ncbi.nlm.nih.gov/pubmed/36911939
http://dx.doi.org/10.3233/JAD-221097
Descripción
Sumario:Major depressive disorder (MDD) is a risk factor for Alzheimer’s disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD burden. Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups: mild cognitive impairment (MCI) (n = 12), MCI with remitted MDD (MDD+MCI) (n = 12), and remitted MDD alone (MDD) (n = 7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers.

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