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Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease
Major depressive disorder (MDD) is a risk factor for Alzheimer’s disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
IOS Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200207/ https://www.ncbi.nlm.nih.gov/pubmed/36911939 http://dx.doi.org/10.3233/JAD-221097 |
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| author | Golas, Angela C. Salwierz, Patrick Rajji, Tarek K. Bowie, Christopher R. Butters, Meryl A. Fischer, Corinne E. Flint, Alastair J. Herrmann, Nathan Mah, Linda Mulsant, Benoit H. Pollock, Bruce G. Taghdiri, Foad Wang, Wei Tartaglia, M. Carmela |
| author_facet | Golas, Angela C. Salwierz, Patrick Rajji, Tarek K. Bowie, Christopher R. Butters, Meryl A. Fischer, Corinne E. Flint, Alastair J. Herrmann, Nathan Mah, Linda Mulsant, Benoit H. Pollock, Bruce G. Taghdiri, Foad Wang, Wei Tartaglia, M. Carmela |
| author_sort | Golas, Angela C. |
| collection | PubMed |
| description | Major depressive disorder (MDD) is a risk factor for Alzheimer’s disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD burden. Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups: mild cognitive impairment (MCI) (n = 12), MCI with remitted MDD (MDD+MCI) (n = 12), and remitted MDD alone (MDD) (n = 7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers. |
| format | Online Article Text |
| id | pubmed-10200207 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | IOS Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-102002072023-05-22 Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease Golas, Angela C. Salwierz, Patrick Rajji, Tarek K. Bowie, Christopher R. Butters, Meryl A. Fischer, Corinne E. Flint, Alastair J. Herrmann, Nathan Mah, Linda Mulsant, Benoit H. Pollock, Bruce G. Taghdiri, Foad Wang, Wei Tartaglia, M. Carmela J Alzheimers Dis Short Communication Major depressive disorder (MDD) is a risk factor for Alzheimer’s disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD burden. Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups: mild cognitive impairment (MCI) (n = 12), MCI with remitted MDD (MDD+MCI) (n = 12), and remitted MDD alone (MDD) (n = 7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers. IOS Press 2023-04-18 /pmc/articles/PMC10200207/ /pubmed/36911939 http://dx.doi.org/10.3233/JAD-221097 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Short Communication Golas, Angela C. Salwierz, Patrick Rajji, Tarek K. Bowie, Christopher R. Butters, Meryl A. Fischer, Corinne E. Flint, Alastair J. Herrmann, Nathan Mah, Linda Mulsant, Benoit H. Pollock, Bruce G. Taghdiri, Foad Wang, Wei Tartaglia, M. Carmela Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease |
| title | Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease |
| title_full | Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease |
| title_fullStr | Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease |
| title_full_unstemmed | Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease |
| title_short | Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease |
| title_sort | assessing the role of past depression in patients with mild cognitive impairment, with and without biomarkers for alzheimer’s disease |
| topic | Short Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200207/ https://www.ncbi.nlm.nih.gov/pubmed/36911939 http://dx.doi.org/10.3233/JAD-221097 |
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